Northern Prickly Ash

Botanical Overview

Northern Prickly Ash (Zanthoxylum americanum) is a flowering plant in the Rutaceae family. Traditional medicine systems have documented several valuable applications for this species, supported by its observed therapeutic effects. The citrus family (Rutaceae) includes trees and shrubs with gland-dotted leaves that release aromatic oils when crushed. The flowers are typically white with four or five petals, and the fruits are often modified berries with a leathery rind. Most species produce alkaloids and limonoids with medicinal activity.

General Description

It is the northernmost New World species in the citrus family, Rutaceae, and is the type species in its genus, which includes sichuan pepper. It can grow to 10 meters (33 ft) tall with a diameter at breast height (DBH) of 15 cm (5. 9 in). It produces membranous leaflets and axillary flower clusters. The wood is not commercially valuable, but oil extracts from the bark have been used in traditional and alternative medicine and have been studied for antifungal and cytotoxic properties. The genus name is sometimes spelled Xanthoxylum.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Rutaceae family is primarily tropical and subtropical. Notable medicinal members include:

Geographic Distribution

Northern Prickly Ash has been recorded in 10 countries and territories worldwide, including Bolivia, Belarus, Canada, Spain, France, and others.

Traditional Uses

Northern Prickly Ash has been traditionally used for digestive health, respiratory conditions, and skin and wound care, among other applications.

Digestive health.

  • Colic

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Respiratory conditions.

  • Cough
  • Expectorant

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Skin and wound care.

  • Sore
  • Wound

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Active Compounds

Phytochemical research has identified 28 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
  • Tannin: astringent compounds that tighten tissues and resist infection
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Bolivia, Belarus, Canada, Spain, France, Mexico, Poland, Ukraine, United States, Unknown.

Complete Use Records

CategoryCultural Context
Ache(Tooth)US, US(Amerindian), US(Appalachia)
ColicUS(Amerindian), US(Appalachia)
RheumatismUS, US(Amerindian)
CoughUS
MedicineUS(Appalachia)
PoulticeUS(Amerindian)
SialogogueUS
SoreUS(Amerindian)
SpasmUS
StomatitisUS
SudorificUS
TonicUS
CancerUS
GonorrheaUS(Amerindian)
SuppurativeUS(Amerindian)
ExpectorantUS
StimulantMexico
WoundUS(Amerindian)

Complete Chemical Inventory

CompoundFormulaMW
(+)-LAURIFOLINEC₂₀H₂₄NO₄+342.4 Da
8-(3,3-DIMETHYLALLYL)ALLOXANTHOXYLETIN
ALLOXANTHOXYLETINC₁₅H₁₄O₄258.27 Da
BERBERINEC₂₀H₁₈NO₄+336.4 Da
BETA-FAGARINEC₁₄H₁₃NO₄259.26 Da
BETA-SITOSTEROLC₂₉H₅₀O414.7 Da
CANDICINEC₁₁H₁₈NO+180.27 Da
CHELERYTHRINEC₂₁H₁₈NO₄+348.4 Da
CNIDILINC₁₇H₁₆O₅300.30 Da
GAMMA-FAGARINEC₁₃H₁₁NO₃229.23 Da
HERCLAVINE
IMPERATORINC₁₆H₁₄O₄270.28 Da
ISOIMPERATORINC₁₆H₁₄O₄270.28 Da
LAURIFOLINEC₂₀H₂₄NO₄+342.4 Da
MAGNOFLORINEC₂₀H₂₄NO₄+342.4 Da
NITIDINEC₂₁H₁₈NO₄+348.4 Da
O-METHYLTYRAMINE-N-METHYL-CINNAMIDE
PSORALENC₁₁H₆O₃186.16 Da
RESINSC₃₀H₅₀O₁₁586.7 Da
SKIMMIANINEC₁₄H₁₃NO₄259.26 Da
TAMBETARINE
TANNINS
TEMBETARINEC₂₀H₂₆NO₄+344.4 Da
XAMTHOXYLETIN
XANTHOTOXINC₁₂H₈O₄216.19 Da
XANTHOXYLETINC₁₅H₁₄O₄258.27 Da
XANTHOXYLINC₁₀H₁₂O₄196.20 Da
XANTHYLETINC₁₄H₁₂O₃228.24 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources