Vervain

Botanical Overview

Commonly known as Vervain, this species belongs to the Verbenaceae family. This species holds a prominent place in the global materia medica, with an extensive record of traditional use spanning diverse cultures and medical systems. The verbena family (Verbenaceae) includes herbs, shrubs, and trees with opposite leaves and spikes or clusters of small, tubular flowers with four or five petals. Many species produce aromatic oils in glandular hairs on their leaves and stems.

General Description

It grows up to 70 cm (28 in) high, with an upright habitus. The lobed leaves are toothed, and the delicate spikes hold clusters of two-lipped mauve flowers. This plant prefers limey soils; it is occasionally grown as an ornamental plant but perhaps more often for the powerful properties some herbalists ascribe to it. Propagation is by root cuttings or seed. It is widely naturalised outside its native range, for example in North America.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Verbenaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Vervain has been recorded in 10 countries and territories worldwide, including Austria, Australia, Belgium, Switzerland, Germany, and others.

Traditional Uses

Vervain has been traditionally used for digestive health, respiratory conditions, and skin and wound care, among other applications.

Digestive health.

  • Vermifuge

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Respiratory conditions.

  • Bronchitis

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Skin and wound care.

  • Wound
  • Sore

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Active Compounds

Phytochemical research has identified 21 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
  • Tannin: astringent compounds that tighten tissues and resist infection
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Austria, Australia, Belgium, Switzerland, Germany, Spain, France, United Kingdom, Italy, Netherlands.

Complete Use Records

CategoryCultural Context
FeverElsewhere, Europe, Sudan, Turkey
TumorBrazil, China, Japan, Mexico
AstringentElsewhere, Eurasia, Turkey
DiureticChina, Eurasia, Turkey
EmmenagogueChina, Elsewhere, Eurasia
DropsyChina, Mexico
LactogogueKurdistan, Turkey
RheumatismElsewhere, Sudan
RubefacientElsewhere, Sudan
TonicSudan, Turkey
WoundElsewhere, Eurasia
AphrodisiacIraq, Turkey
LiverItaly(Tuscany), Spain
AmenorrheaChina
BiliousMexico
Bite(Snake)Sudan
BronchitisAfrica
DeobstruentChina
DetersiveTurkey
EdemaChina
Gall-BladderItaly(Tuscany)
HepatitisChina
PoisonAustralia
ScrofulaSudan
ScurvyTurkey
SoreEurasia
SpasmTurkey
TraumaChina
Tumor(Throat)Argentina
VermifugePortugal*

Complete Chemical Inventory

CompoundFormulaMW
(+)-VERBENONEC₁₀H₁₄O150.22 Da
5-HYDROXY-3,6,7,3',4'-PENTAMETHOXYFLAVONEC₂₀H₂₀O₈388.4 Da
ADENOSINEC₁₀H₁₃N₅O₄267.24 Da
ALPHA-SITOSTEROLC₃₀H₅₀O426.7 Da
ARTEMITINC₂₀H₂₀O₈388.4 Da
AUCUBINC₁₅H₂₂O₉346.33 Da
BETA-CAROTENEC₄₀H₅₆536.9 Da
CAFFEIC-ACIDC₉H₈O₄180.16 Da
CITRALC₁₀H₁₆O152.23 Da
EMULSIN
HASTATOSIDEC₁₇H₂₄O₁₁404.4 Da
INVERTINC₂₂H₂₆N₂O₉462.4 Da
LUPEOLC₃₀H₅₀O426.7 Da
MUCILAGE
STACHYOSEC₂₄H₄₂O₂₁666.6 Da
TANNIN
TERPENENE
URSOLIC-ACIDC₃₀H₄₈O₃456.7 Da
VERBENALINC₁₇H₂₄O₁₀388.4 Da
VERBENALOLC₁₁H₁₄O₅226.23 Da
VERBENIN

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources