Red Clover

Also known as: Purple Clover, Peavine Clover, Cowgrass

Botanical Overview

Red Clover (Trifolium pratense) is a flowering plant in the Fabaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. The legume family (Fabaceae) includes trees, shrubs, and herbs that produce pods (legumes) and form nitrogen-fixing root nodules through symbiosis with bacteria. The flowers are typically pea-shaped with five petals. This large family provides food staples, timber, and numerous medicinal species.

General Description

It is native to the Old World, but planted and naturalised in many other regions.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Fabaceae family is large and globally distributed. Notable medicinal members include:

Geographic Distribution

Red Clover has been recorded in 10 countries and territories worldwide, including Belgium, Switzerland, Germany, Denmark, Finland, and others.

Traditional Uses

Red Clover has been traditionally used for digestive health, respiratory conditions, and skin and wound care, among other applications.

Digestive health.

  • Dyspepsia

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Respiratory conditions.

  • Expectorant
  • Bronchitis
  • Catarrh
  • Cough
  • Asthma

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Skin and wound care.

  • Sore
  • Burn
  • Skin

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Flavonoid: antioxidant compounds that protect cells from oxidative damage
  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Belgium, Switzerland, Germany, Denmark, Finland, France, United Kingdom, Netherlands, Sweden, United States.

Complete Use Records

CategoryCultural Context
SedativeElsewhere, Eurasia, Turkey, US
AlterativeElsewhere, Eurasia, Turkey
CancerElsewhere, UK, US
SoreElsewhere, Iraq, US
BurnAmerindian, US(Amerindian)
ExpectorantElsewhere, Iraq
EyeAmerindian, US(Amerindian)
PertussisIraq, US
SpasmElsewhere, Turkey
BronchitisIraq
CatarrhSpain
CornElsewhere
CoughUS
SkinUS
TonicTurkey
TumorSpain
WhitlowUSSR
AsthmaIraq
DiureticTurkey
Cancer(Bowel)Australia
DepurativeElsewhere
DyspepsiaEurope
ScrofulaTurkey

Complete Chemical Inventory

CompoundFormulaMW
(-)-MAACKIAIN-3-O-GLUCOSIDEC₂₂H₂₂O₁₀446.4 Da
(E)-2-HEXENALC₆H₁₀O98.14 Da
(E)-2-HEXENOLC₆H₁₂O100.16 Da
(E)-LINALOL-OXIDE
(E)-LINALOOL-OXIDE
(Z)-1-HEXEN-3-OL
(Z)-3-HEXENOLC₆H₁₂O100.16 Da
(Z)-3-HEXENYL-ACETATE
(Z)-LINALOL-OXIDE
(Z)-LINALOOL-OXIDE
1-OCTEN-3-OLC₈H₁₆O128.21 Da
1-PHENYLETHANOLC₈H₁₀O122.16 Da
1-PHENYLETHYL-ALCOHOLC₈H₁₀O122.16 Da
2,4-METHYLENE-CHOLESTEROLC₂₈H₄₆O398.7 Da
2-ETHYLHEXANALC₈H₁₆O128.21 Da
2-METHYL-BUTAN-1-OLC₅H₁₂O88.15 Da
2-PHENYLETHAN-1-OLC₈H₁₀O122.16 Da
2-PHENYLETHANOLC₈H₁₀O122.16 Da
2-PHENYLETHYL-ALCOHOLC₈H₁₀O122.16 Da
3-BUTYLPHTHALIDEC₁₂H₁₄O₂190.24 Da
3-METHYLQUERCETINC₁₆H₁₂O₇316.26 Da
3-METHYLQUERCETIN-7-O-BETA-D-GLUCOSIDE-6''-O-MALONATE
3-P-COUMAROYLQUININE
4',5-DIHYDROXY-6,7-METHYLENEDIOXY-ISOFLAVONE
4-METHOXYMEDICARPINC₁₇H₁₆O₅300.30 Da
6-ALPHA-7-DIHYDROXYMAACKIAIN
6-ALPHA-7-DIHYDROXYMEDICARPIN
6-ALPHA-HYDROXYMAACKIAIN
6-ALPHA-HYDROXYMEDICARPIN
6-ALPHA-METHOXY-MAACKIAIN

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources