Nux-Vomica

Also known as: Stychnine

Botanical Overview

Nux-Vomica (Strychnos nux-vomica) is a flowering plant in the Loganiaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. This species belongs to the Loganiaceae family, a group of flowering plants.

General Description

It is a medium-sized tree in the family Loganiaceae that grows in open habitats. Its leaves are ovate and 5–9 centimetres (2–3. 5 in) in size. It is known for being the natural source of the extremely poisonous compound strychnine.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Loganiaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Nux-Vomica has been recorded in 10 countries and territories worldwide, including Ivory Coast, China, India, Cambodia, Laos, and others.

Traditional Uses

Nux-Vomica has been traditionally used for digestive health, respiratory conditions, and skin and wound care, among other applications.

Digestive health.

  • Colic
  • Laxative

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Respiratory conditions.

  • Asthma

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Skin and wound care.

  • Sore
  • Wound

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Toxicity warning: Contains strychnine, a potent neurotoxin. Traditional records: This plant has documented uses including Poison, Emetic, Abortifacient. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Ivory Coast, China, India, Cambodia, Laos, Sri Lanka, Thailand, United States, Vietnam, Unknown.

Complete Use Records

CategoryCultural Context
PoisonChina, Elsewhere, Malaysia, South America, Turkey
CanicideChina, Elsewhere, Malaysia, Turkey
FeverChina, Elsewhere, India
TonicIndia, Malaysia, Turkey
FatalityAsia, Elsewhere
SoreChina, Elsewhere
StimulantIndia, Turkey
AmblyopiaElsewhere
AphrodisiacElsewhere
AsthmaElsewhere
AvicideTurkey
CancerChina
ChoreaElsewhere
ColicIndia
CynancheChina
EmeticCambodia
EpilepsyElsewhere
Hair-OilElsewhere
LaxativeTurkey
OphthalmiaElsewhere
Poison(Arrow)Elsewhere
Sore(Throat)China
VasoconstrictorTurkey
WoundElsewhere
AgueChina
NervesIndia
TumorIndia
AbortifacientChina
InsecticideElsewhere
MyocarditisElsewhere

Complete Chemical Inventory

CompoundFormulaMW
16-HYDROXY-ALPHA-COLUBRINE
16-HYDROXY-BETA-COLUBRINE
3-METHOXYICAJINE
4-DEOXYLOGANINC₁₇H₂₆O₉374.4 Da
ALKALOIDS
ALPHA-AMYRINC₃₀H₅₀O426.7 Da
ALPHA-COLUBRINEC₂₂H₂₄N₂O₃364.4 Da
ARABINOSEC₅H₁₀O₅150.13 Da
ARACHIDIC-ACIDC₂₀H₄₀O₂312.5 Da
BEHENIC-ACIDC₂₂H₄₄O₂340.6 Da
BETA-COLUBRINEC₂₂H₂₄N₂O₃364.4 Da
BRUCINEC₂₃H₂₆N₂O₄394.5 Da
BRUCINE-N-OXIDEC₂₃H₂₆N₂O₅410.5 Da
C-MAVACURINEC₂₀H₂₅N₂O+309.4 Da
CHLOROGENIC-ACIDC₁₆H₁₈O₉354.31 Da
CHOLINEC₅H₁₄NO+104.17 Da
CONDYLOCARPINEC₂₀H₂₂N₂O₂322.4 Da
CYCLOARTENOLC₃₀H₅₀O426.7 Da
DIABOLINEC₂₁H₂₄N₂O₃352.4 Da
FATC₁₆H₃₂O₂256.42 Da
GALACTOSEC₆H₁₂O₆180.16 Da
GEISSOSCHIZINEC₂₁H₂₄N₂O₃352.4 Da
HYDROXYSTRYCHNINEC₂₁H₂₂N₂O₃350.4 Da
ICAJINEC₂₂H₂₄N₂O₃364.4 Da
ISOSTRYCHNINEC₂₁H₂₂N₂O₂334.4 Da
LINOLEIC-ACIDC₁₈H₃₂O₂280.4 Da
LOGANIC-ACIDC₁₆H₂₄O₁₀376.36 Da
LOGANINC₁₇H₂₆O₁₀390.4 Da
MANNOSEC₆H₁₂O₆180.16 Da
MYRISTIC-ACIDC₁₄H₂₈O₂228.37 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources