Kombe Arrow Poison

Botanical Overview

Kombe Arrow Poison (Strophanthus kombe) belongs to the Apocynaceae family. While not among the most extensively documented medicinal plants, this species has recorded uses that warrant attention from researchers and practitioners. The dogbane family (Apocynaceae) includes herbs, shrubs, vines, and trees with milky sap containing alkaloids and cardiac glycosides. The flowers are typically five-petaled and often showy with a tubular corolla. Many species in this family are highly toxic but also source of important cardiac medications.

General Description

S. kombe contains a cardiac glycoside which directly affects the heart. Historically, both the seeds and roots of the plant were used in the preparation of poison arrowheads used for hunting. Today, the seeds are used pharmaceutically for patients with certain heart conditions that affect blood circulation. The seeds are traded primarily with Europe, but have also been exported to the United States and Japan.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Apocynaceae family is primarily tropical and subtropical. Notable medicinal members include:

Geographic Distribution

Kombe Arrow Poison has been recorded in 10 countries and territories worldwide, including Angola, Congo (DRC), Kenya, Malawi, Mozambique, and others.

Traditional Uses

Kombe Arrow Poison has been traditionally used for urinary tract health and cardiovascular health.

Urinary tract health.

  • Diuretic

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Cardiovascular health.

  • Heart

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Flavonoid: antioxidant compounds that protect cells from oxidative damage
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Angola, Congo (DRC), Kenya, Malawi, Mozambique, Namibia, Tanzania, South Africa, Zambia, Zimbabwe.

Complete Use Records

CategoryCultural Context
Poison(Arrow)Africa, Africa(Swahili)
CardiotonicAfrica
DiureticAfrica
HeartIndia
PoisonAfrica(Swahili)
StimulantAfrica

Complete Chemical Inventory

CompoundFormulaMW
17-BETA-H-STROPHANTHOSIDE
ALLO-CYMARIN
CARDENOLIDES
CYMARINC₃₀H₄₄O₉548.7 Da
CYMAROLC₃₀H₄₆O₉550.7 Da
CYMAROSEC₇H₁₄O₄162.18 Da
EMICYMARINC₃₀H₄₆O₉550.7 Da
ERYSIMOL
ERYSIMOSIDEC₃₅H₅₂O₁₄696.8 Da
ERYSIMOSOLC₃₅H₅₄O₁₄698.8 Da
GLUCOCYMAROL
GLUCOHELVETICOSIDE
HELVETICOSIDEC₂₉H₄₂O₉534.6 Da
ISOEMICYMARIN
ISOPERIPLOCYMARIN
K-STROPHANTHIN-BETAC₃₆H₅₄O₁₄710.8 Da
K-STROPHANTHOL-GAMMA
K-STROPHANTHOSIDEC₄₂H₆₄O₁₉872.9 Da
MUSAROSIDEC₃₀H₄₄O₁₀564.7 Da
NEOGLUCOERYSIMOSIDEC₃₅H₅₂O₁₄696.8 Da
PANSTROSIDEC₃₀H₄₄O₁₀564.7 Da
PERIPLOCYMARINC₃₀H₄₆O₈534.7 Da
PERIPLOGENINC₂₃H₃₄O₅390.5 Da
STROPHANTHIDINC₂₃H₃₂O₆404.5 Da
STROPHANTHIDIN-GLYCOSIDE
STROPHANTHIDIOL
STROPHANTHIDOLC₂₃H₃₄O₆406.5 Da
STROPHANTHIDOL-DIGITOXOSIDO-GLUCOSIDE
STROPHANTHOSIDE-19-CARBOXYLIC-ACID
TRIGONELLINEC₇H₇NO₂137.14 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources