Ca-A-E

Also known as: Sweet Leaf of Paraguay, Stevia

Botanical Overview

Ca-A-E (Stevia rebaudiana) belongs to the Asteraceae family. While not among the most extensively documented medicinal plants, this species has recorded uses that warrant attention from researchers and practitioners. The daisy family (Asteraceae) is one of the largest plant families, characterized by composite flower heads (capitula) that contain many small florets surrounded by bracts. Plants range from tiny alpine herbs to large tropical trees. The family includes many medicinally important species with bitter compounds and essential oils.

General Description

It is commonly known as candyleaf, sweetleaf or sugarleaf. It is a small seasonal plant which grows to a height of 30–60 centimetres (1–2 feet). It has elongated leaves that grow along the stems and are lined up against each other. The flowers are typically trimmed to improve the taste of the leaves. Stevia is a tender perennial native to parts of Brazil and Paraguay having humid, wet environments. Stevia is widely grown for its leaves, from which extracts can be manufactured as sweetener products known generically as stevia and sold under various trade names. The chemical compounds that produce its sweetness are various steviol glycosides (mainly stevioside and rebaudioside), which have 200–300 times the sweetness of sugar. Stevia leaves contain 9. 1% stevioside and 3. 8% rebaudioside A.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Asteraceae family is extremely large and diverse. Notable medicinal members include:

Geographic Distribution

Ca-A-E has been recorded in 10 countries and territories worldwide, including Argentina, Brazil, China, Colombia, Cuba, and others.

Traditional Uses

Ca-A-E has been traditionally used for reproductive health.

Reproductive health.

  • Contraceptive

In traditional contexts, reproductive health applications typically involve internal preparations such as teas or decoctions. The herb may be taken at specific times during the menstrual cycle.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Flavonoid: antioxidant compounds that protect cells from oxidative damage
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Argentina, Brazil, China, Colombia, Cuba, Spain, Japan, Paraguay, Taiwan, United States.

Complete Use Records

CategoryCultural Context
SweetenerParaguay
ContraceptiveParaguay

Complete Chemical Inventory

CompoundFormulaMW
(-)-KAURENEC₂₀H₃₂272.5 Da
1,8-CINEOLEC₁₀H₁₈O154.25 Da
2-PENTYL-FURANC₉H₁₄O138.21 Da
5,7,3'-TRIHYDROXY-3,6,4'-TRIMETHOXY-FLAVONE
6-DEOXYAUSTROINULIN
6-O-ACETYLAUSTROINULINC₂₂H₃₆O₄364.5 Da
6-O-AUSTROINULIN
7-O-ACETYLAUSTROINULINC₂₂H₃₆O₄364.5 Da
ALPHA-BERGAMOTENEC₁₅H₂₄204.35 Da
ALPHA-CADINOLC₁₅H₂₆O222.37 Da
ALPHA-CALACORENEC₁₅H₂₀200.32 Da
ALPHA-COPAENEC₁₅H₂₄204.35 Da
ALPHA-CUBEBENEC₁₅H₂₄204.35 Da
ALPHA-HUMULENEC₁₅H₂₄204.35 Da
ALPHA-PINENEC₁₀H₁₆136.23 Da
ALPHA-TERPINEOLC₁₀H₁₈O154.25 Da
ALUMINUMAl26.981538 Da
ANETHOLEC₁₀H₁₂O148.20 Da
APIGENIN-4'-O-GLUCOSIDEC₂₁H₂₀O₁₀432.4 Da
ASCORBIC-ACIDC₆H₈O₆176.12 Da
ASH
AUSTROINULINC₂₀H₃₄O₃322.5 Da
BENZYL-ALCOHOLC₇H₈O108.14 Da
BETA-AMYRIN-ACETATEC₃₂H₅₂O₂468.8 Da
BETA-BOURBONENEC₁₅H₂₄204.35 Da
BETA-CAROTENEC₄₀H₅₆536.9 Da
BETA-CARYOPHYLLENEC₁₅H₂₄204.35 Da
BETA-CUBEBENEC₁₅H₂₄204.35 Da
BETA-ELEMENEC₁₅H₂₄204.35 Da
BETA-IONONEC₁₃H₂₀O192.30 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources