Rue

Botanical Overview

Commonly known as Rue, this species belongs to the Rutaceae family. Across multiple healing traditions, this plant has earned recognition as a versatile medicinal species with applications ranging from first-aid to chronic disease management. The citrus family (Rutaceae) includes trees and shrubs with gland-dotted leaves that release aromatic oils when crushed. The flowers are typically white with four or five petals, and the fruits are often modified berries with a leathery rind. Most species produce alkaloids and limonoids with medicinal activity.

General Description

It is native to the Mediterranean. It is grown throughout the world in gardens, especially for its bluish leaves, and sometimes for its tolerance of hot and dry soil conditions. It is also cultivated as a culinary herb, and to a lesser extent as an insect repellent and incense.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Rutaceae family is primarily tropical and subtropical. Notable medicinal members include:

Geographic Distribution

Rue has been recorded in 10 countries and territories worldwide, including Belgium, Brazil, Switzerland, Germany, Spain, and others.

Traditional Uses

Rue has been traditionally used for digestive health, respiratory conditions, and urinary tract health, among other applications.

Digestive health.

  • Carminative
  • Vermifuge

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Respiratory conditions.

  • Cold
  • Cough

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Urinary tract health.

  • Diuretic

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Abortifacient, Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Belgium, Brazil, Switzerland, Germany, Spain, France, United Kingdom, Italy, Netherlands, United States.

Complete Use Records

CategoryCultural Context
AbortifacientElsewhere, Mediterranean, Mexico, Turkey, US
EmmenagogueChina, Elsewhere, Mediterranean, Mexico, Turkey
FeverChina, Malaya, South Africa
SpasmChina, Mediterranean, Turkey
AmenorrheaElsewhere, Mexico
AnaphrodisiacElsewhere, Java
CancerEurope, Norway
CarminativeChina, US
ConvulsionMalaya, US
EpilepsyElsewhere, US
HemostatChina, Turkey
HysteriaElsewhere, Java
RheumatismElsewhere, US
StimulantElsewhere, Turkey
Ache(Tooth)China, Elsewhere
VermifugeChina, Turkey
PoisonMexico, Turkey
Ache(Ear)Elsewhere
Ache(Head)Mexico
AntidoteChina
ApertifTurkey
ArthritisElsewhere
BactericideElsewhere
Bite(Bug)China
Bite(Snake)China
ColdChina
CoughJava
DetersiveTurkey
DigestiveTurkey
DiureticElsewhere

Complete Chemical Inventory

CompoundFormulaMW
1-(4',4'-DIMETHYLHEXEN-5'-YL)-3,4-METHYLENEDIOXYBENZOL
1-HYDROXY-3-METHOXY-N-METHYLACRIDONEC₁₅H₁₃NO₃255.27 Da
1-METHYL-2-N-NONYL-4-QUINOLONE
2-(4-(3,4-METHYLENEDIOXYPHENYL)-BUTYL)-4-QUINOLINE
2-DECANONEC₁₀H₂₀O156.26 Da
2-DECYL-ALCOHOLC₁₀H₂₂O158.28 Da
2-HEPTANOLC₇H₁₆O116.20 Da
2-HEPTANONEC₇H₁₄O114.19 Da
2-N-DODECYL-1,4-QUINOLONE
2-N-TETRADECYL-4-QUINOLONE
2-N-TRIDECYL-4-QUINOLONE
2-N-UNDECYL-4-QUINOLONE
2-NONANOLC₉H₂₀O144.25 Da
2-NONANONEC₉H₁₈O142.24 Da
2-NONYL-ALCOHOLC₉H₂₀O144.25 Da
2-OCTANONEC₈H₁₆O128.21 Da
2-UNDECANOLC₁₁H₂₄O172.31 Da
2-UNDECANONEC₁₁H₂₂O170.29 Da
2-UNDECYLALCOHOL
3-(1',1'-DIMETHYLALLYL)-8-(3',3'-DIMETHYLALLYL)-XANTHYLETIN
3-(1',1'-DIMETHYLALLYL)-DAPHNETINDIMETHYLETHER
3-(1',1'-DIMETHYLALLYL)-HERNIARIN
6-METHOXYDICTAMNINEC₁₃H₁₁NO₃229.23 Da
8-METHOXYGRAVELLIFERONEC₂₀H₂₄O₄328.4 Da
ALPHA-PINENEC₁₀H₁₆136.23 Da
ANISIC-ACIDC₈H₈O₃152.15 Da
ARBORININEC₁₆H₁₅NO₄285.29 Da
ASCORBIC-ACIDC₆H₈O₆176.12 Da
BERGAPTENC₁₂H₈O₄216.19 Da
BETA-PINENEC₁₀H₁₆136.23 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources