Madder

Botanical Overview

Madder (Rubia cordifolia) is a flowering plant in the Rubiaceae family. The traditional uses of this species reflect its genuine medicinal value, validated by generations of practical experience. The coffee family (Rubiaceae) includes trees, shrubs, and herbs with opposite leaves and interpetiolar stipules. The flowers are typically tubular with four or five petals. The family includes coffee (Coffea), quinine-producing Cinchona, and numerous other medicinal species with alkaloid constituents.

General Description

It has been cultivated for a red pigment derived from roots.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Rubiaceae family is large and primarily tropical. Notable medicinal members include:

Geographic Distribution

Madder has been recorded in 10 countries and territories worldwide, including Congo (DRC), China, Ethiopia, India, Japan, and others.

Traditional Uses

Madder has been traditionally used for digestive health, skin and wound care, and urinary tract health, among other applications.

Digestive health.

  • Vermifuge

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Skin and wound care.

  • Skin
  • Ulcer

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Urinary tract health.

  • Edema

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Congo (DRC), China, Ethiopia, India, Japan, South Korea, Pakistan, Russia, Tanzania, South Africa.

Complete Use Records

CategoryCultural Context
TonicChina, Elsewhere
AbdomenChina
AlterativeChina
AnodyneChina
ArthritisChina
AstringentChina
BloodChina
DepurativeChina
DivinationLesotho
EdemaChina
EmmenagogueChina
EpistaxisChina
FractureChina
HematemesisChina
HemoptysisChina
HemorrhageChina
HemostatChina
InflammationChina
JaundiceChina
ParalysisNepal
PilesChina
RefrigerantChina
RheumatismChina
RheumatitisChina
SkinElsewhere
ToothhpasteLesotho
TraumaChina
UlcerNepal
VermifugeElsewhere
VulneraryChina

Complete Chemical Inventory

CompoundFormulaMW
1,3-DIMETHOXY-2-CARBOXYANTHRAQUINONE
1,4-DIHYDROXY-2-CARBOETHOXYANTHRAQUINONEC₁₇H₁₂O₆312.27 Da
1,4-DIHYDROXY-2-METHYL-5-METHOXYANTHRAQUINONEC₁₆H₁₂O₅284.26 Da
1,4-DIHYDROXY-2-METHYLANTHRAQUINONEC₁₅H₁₀O₄254.24 Da
1,5-DIHYDROXY-2-METHYLANTHRAQUINONEC₁₅H₁₀O₄254.24 Da
1-ACETOXY-6-HYDROXY-2-METHYLANTHRAQUINONE-3-O-ALPHA-RHAMNOSYL...
1-HYDROXY-2-CARBOXY-3-METHOXYANTHRAQUINONEC₁₆H₁₀O₆298.25 Da
1-HYDROXY-2-METHOXYANTHRAQUINONEC₁₅H₁₀O₄254.24 Da
1-HYDROXY-2-METHYL-6-METHOXYANTHRAQUINONEC₁₆H₁₂O₄268.26 Da
1-HYDROXY-2-METHYL-7-METHOXYANTHRAQUINONE
1-HYDROXY-2-METHYL-ANTHRAQUINONEC₁₅H₁₀O₃238.24 Da
5,8-DIHYDROXY-2-METHYLANTHRAQUINONE
ALIZARINC₁₄H₈O₄240.21 Da
ANTHRAQUINONESC₁₄H₈O₂208.21 Da
ARSENICAs74.92159 Da
BETA-SITOSTEROLC₂₉H₅₀O414.7 Da
CALCIUMCa40.08 Da
COPPERCu63.55 Da
HEXAPEPTIDES
IRONFe55.84 Da
MAGNESIUMMg24.305 Da
MANGANESEMn54.93804 Da
MUNJISTINE
NOR-DAMNACANTHAL
OLEANOLIC-ACID-ACETATEC₃₂H₅₀O₄498.7 Da
PHYSCIONC₁₆H₁₂O₅284.26 Da
POTASSIUMK39.0983 Da
PSEUDOPURPURINC₁₅H₈O₇300.22 Da
PURPURINC₁₄H₈O₅256.21 Da
PURPUROXANTHINS

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources