African Snakeroot

Botanical Overview

African Snakeroot (Rauvolfia vomitoria) is a flowering plant in the Apocynaceae family. Traditional medicine systems have documented several valuable applications for this species, supported by its observed therapeutic effects. The dogbane family (Apocynaceae) includes herbs, shrubs, vines, and trees with milky sap containing alkaloids and cardiac glycosides. The flowers are typically five-petaled and often showy with a tubular corolla. Many species in this family are highly toxic but also source of important cardiac medications.

Family Context

The Apocynaceae family is primarily tropical and subtropical. Notable medicinal members include:

Geographic Distribution

African Snakeroot has been recorded in 10 countries and territories worldwide, including Benin, Congo (DRC), Ivory Coast, Cameroon, Gabon, and others.

Traditional Uses

African Snakeroot has been traditionally used for digestive health, skin and wound care, and pain and inflammation, among other applications.

Digestive health.

  • Purgative
  • Dyspepsia

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Skin and wound care.

  • Skin
  • Leprosy
  • Psoriasis

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Pain and inflammation.

  • Rheumatism
  • Swelling

For pain and inflammation, preparations are applied both topically as compresses and taken internally. A warm poultice draws blood to the area and promotes healing, while internal preparations address systemic inflammation.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Purgative, Emetic. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Benin, Congo (DRC), Ivory Coast, Cameroon, Gabon, Ghana, Guinea, Equatorial Guinea, Nigeria, United States.

Complete Use Records

CategoryCultural Context
AphrodisiacAfrica, Upper Volta
Bite(Snake)Nigeria, Upper Volta
ConvulsionAfrica, Ghana
ErysipelasAfrica, Ghana
GonorrheaIvory Coast, Nigeria
JaundiceGhana, Nigeria
MeaslesAfrica, Ghana
PurgativeAfrica, Ghana
SedativeAfrica, Nigeria
EmeticAfrica, Upper Volta
SkinAfrica, W Africa
CongestionUpper Volta
DyspepsiaW Africa
FeverLiberia
HerpesGhana
LeprosyUpper Volta
RheumatismGhana
SprainGhana
SwellingGhana
VertigoGhana
UrethrumGhana
UrticariaGhana
YawsW Africa
DislocationGhana
GastritisNigeria
PediculicideE Africa
PsoriasisUpper Volta
EnteritisNigeria

Complete Chemical Inventory

CompoundFormulaMW
17-ACETYL-AJMALINE
AJMALICINEC₂₁H₂₄N₂O₃352.4 Da
AJMALINEC₂₀H₂₆N₂O₂326.4 Da
AJMALININE
ALPHA-YOHIMBINEC₂₁H₂₆N₂O₃354.4 Da
ALSTONINEC₂₁H₂₀N₂O₃348.4 Da
ARICINEC₂₂H₂₆N₂O₄382.5 Da
CARAPANAUBINEC₂₃H₂₈N₂O₆428.5 Da
DEACETYLDEFORMYLAKUAMMILINE
DEACETYLDEFORMYLPICRALINE
ISOAJMALINEC₂₀H₂₆N₂O₂326.4 Da
ISOCARAPANAUBINEC₂₃H₂₈N₂O₆428.5 Da
ISORESERPILINEC₂₃H₂₈N₂O₅412.5 Da
ISORESERPILINE-PSEUDOINDOXYLC₂₃H₂₈N₂O₆428.5 Da
ISOSANDWICENE
MITORIDINEC₂₀H₂₂N₂O₂322.4 Da
NEONORRESERPINE
PERAKINEC₂₁H₂₂N₂O₃350.4 Da
PICRININEC₂₀H₂₂N₂O₃338.4 Da
PURPELINE
RAUGALLINEC₂₀H₂₆N₂O₂326.4 Da
RAUMITORINEC₂₂H₂₆N₂O₄382.5 Da
RAUNITIDINEC₂₂H₂₆N₂O₄382.5 Da
RAUVANINEC₂₃H₂₈N₂O₅412.5 Da
RAUVOMILINE
RAUVOMITINEC₃₀H₃₄N₂O₅502.6 Da
RAUVOXINE
RAUVOXININE
RENOXIDINE
RESCIDINEC₃₄H₄₀N₂O₉620.7 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources