Indian Snakeroot

Also known as: Serpentine Wood

Botanical Overview

Indian Snakeroot (Rauvolfia serpentina) is a flowering plant in the Apocynaceae family. The traditional uses of this species reflect its genuine medicinal value, validated by generations of practical experience. The dogbane family (Apocynaceae) includes herbs, shrubs, vines, and trees with milky sap containing alkaloids and cardiac glycosides. The flowers are typically five-petaled and often showy with a tubular corolla. Many species in this family are highly toxic but also source of important cardiac medications.

General Description

It is native to the Indian subcontinent and East Asia (from India to Indonesia). Rauvolfia is a perennial undershrub widely distributed in India in the sub-Himalayan regions up to 1,000 metres (3,300 ft). Sarpagandha is used in folk medicine in India for centuries to treat a wide variety of maladies, including snake and insect bites, febrile conditions, malaria, abdominal pain, and dysentery. It was also used as a uterine stimulant, febrifuge, and cure for insanity. The plant was mentioned in Hindu manuscripts as long ago as 1000 BCE.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Apocynaceae family is primarily tropical and subtropical. Notable medicinal members include:

Geographic Distribution

Indian Snakeroot has been recorded in 10 countries and territories worldwide, including Brazil, Indonesia, India, Sri Lanka, Myanmar, and others.

Traditional Uses

Indian Snakeroot has been traditionally used for nervous system disorders, fever management, and cardiovascular health, among other applications.

Nervous system disorders.

  • Sedative
  • Insomnia

Nervous system support involves taking the herb as a warm tea, often in the evening or before bed. The calming compounds interact with neurotransmitter systems to promote relaxation and restful sleep.

Fever management.

  • Fever

Febrifuge preparations are typically administered as hot teas to induce perspiration, which helps the body regulate temperature. The patient is kept warm and encouraged to rest while the herb promotes sweating.

Cardiovascular health.

  • Hypertension
  • Hypotension

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Brazil, Indonesia, India, Sri Lanka, Myanmar, Nepal, Philippines, Thailand, United States, Unknown.

Complete Use Records

CategoryCultural Context
HypnoticNepal, Sanscrit, Turkey
PoisonAsia, India, Turkey
SedativeChinese, India, Turkey
BrachycardiaSpanish, Turkey
FeverIndia, Turkey
HypertensionIndia, Turkey
HypochondriaIndia, Turkey
InsanityMalaysia, Turkey
InsomniaMalaysia, Turkey
UterotonicMalaysia, Turkey
Bite(Snake)Nepal
HypotensiveNepal
TonicSanscrit
HypotensionEnglish
TranquilizerIndia

Complete Chemical Inventory

CompoundFormulaMW
11-METHOXY-DELTA-TOHIMBINE
2,6-DIMETHOXYBENZOQUINONEC₈H₈O₄168.15 Da
3,4,5-TRIMETHOXYBENZOIC-ACIDC₁₀H₁₂O₅212.20 Da
3-EPI-ALPHA-YOHIMBINEC₂₁H₂₆N₂O₃354.4 Da
AJMALEXINE
AJMALICINEC₂₁H₂₄N₂O₃352.4 Da
AJMALINEC₂₀H₂₆N₂O₂326.4 Da
AJMALININE
ALKALOIDS
ALLOYOHIMBINEC₂₁H₂₆N₂O₃354.4 Da
ASKC₁₃H₁₁NO₂213.23 Da
CALCIUMCa40.08 Da
CHANDRINE
CORYNANTHINEC₂₁H₂₆N₂O₃354.4 Da
DELTA-YOHIMBINEC₂₁H₂₄N₂O₃352.4 Da
DESERPIDINEC₃₂H₃₈N₂O₈578.7 Da
EUDESMIC-ACIDC₁₀H₁₂O₅212.20 Da
FATC₁₆H₃₂O₂256.42 Da
FIBER
GAMMA-YOHIMBINE
ISOAJMALINEC₂₀H₂₆N₂O₂326.4 Da
ISORAUHIMBINEC₂₁H₂₆N₂O₃354.4 Da
ISORAUNITIDINE
ISOSANDWICINE
ISOYOHIMBINEC₂₁H₂₆N₂O₃354.4 Da
METHYL-RESERPATEC₂₃H₃₀N₂O₅414.5 Da
NEOAJMALINE
NITROGENN₂28.014 Da
PAPAVERINEC₂₀H₂₁NO₄339.4 Da
PHOSPHORUSP30.97376200 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources