Calabar Bean

Botanical Overview

Calabar Bean (Physostigma venenosum) is a flowering plant in the Fabaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. The legume family (Fabaceae) includes trees, shrubs, and herbs that produce pods (legumes) and form nitrogen-fixing root nodules through symbiosis with bacteria. The flowers are typically pea-shaped with five petals. This large family provides food staples, timber, and numerous medicinal species.

General Description

It derives the first part of its scientific name from a curious beak-like appendage at the end of the stigma, in the centre of the flower; this appendage, though solid, was originally believed to be hollow.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Fabaceae family is large and globally distributed. Notable medicinal members include:

Geographic Distribution

Calabar Bean has been recorded in 10 countries and territories worldwide, including Congo (DRC), Ivory Coast, Cameroon, Gabon, Ghana, and others.

Traditional Uses

Calabar Bean has been traditionally used for pain and inflammation and nervous system disorders.

Pain and inflammation.

  • Arthritis
  • Rheumatism

For pain and inflammation, preparations are applied both topically as compresses and taken internally. A warm poultice draws blood to the area and promotes healing, while internal preparations address systemic inflammation.

Nervous system disorders.

  • Spasm
  • Sedative

Nervous system support involves taking the herb as a warm tea, often in the evening or before bed. The calming compounds interact with neurotransmitter systems to promote relaxation and restful sleep.

Active Compounds

Phytochemical research has identified 24 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Congo (DRC), Ivory Coast, Cameroon, Gabon, Ghana, Guinea, Equatorial Guinea, Liberia, Nigeria, Sierra Leone.

Complete Use Records

CategoryCultural Context
PoisonAfrica, India, Turkey
Antidote(Atropine)Elsewhere
ArthritisElsewhere
BursitisElsewhere
FibrositisElsewhere
MyoticTurkey
ParasiticideAfrica
PediculicideAfrica
RheumatismElsewhere
SpasmElsewhere
Antidote(Strychnine)Elsewhere
Myasthenia GravisElsewhere
AntidoteElsewhere
Colic(Veterinary)Elsewhere
OrdealAfrica
RaticideAfrica
SedativeTurkey
TetanusElsewhere

Complete Chemical Inventory

CompoundFormulaMW
ALKALOIDS
BEHENIC-ACIDC₂₂H₄₄O₂340.6 Da
BETA-SITOSTEROLC₂₉H₅₀O414.7 Da
CALABACINE
CALABARINEC₁₅H₂₁N₃O₂275.35 Da
CALABAROL
CALABATINE
ESERAMINEC₁₆H₂₂N₄O₃318.37 Da
ESERANINE
ESERIDINEC₁₅H₂₁N₃O₃291.35 Da
ESERINEC₁₅H₂₁N₃O₂275.35 Da
GENESERINEC₁₅H₂₁N₃O₃291.35 Da
ISOPHYSOSTIGMINE
LINOLEIC-ACIDC₁₈H₃₂O₂280.4 Da
N-8-NORPHYSOSTIGMINE
OLEIC-ACIDC₁₈H₃₄O₂282.5 Da
PALMITIC-ACIDC₁₆H₃₂O₂256.42 Da
PHYSOSTERINE
PHYSOVENINEC₁₄H₁₈N₂O₃262.30 Da
PROTEIN
STARCH
STEARIC-ACIDC₁₈H₃₆O₂284.5 Da
STIGMASTEROLC₂₉H₄₈O412.7 Da
TRIFOLIANOL

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources