Harmel

Also known as: Syrian Rue

Botanical Overview

Harmel (Peganum harmala) is a flowering plant in the Zygophyllaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. This species belongs to the Zygophyllaceae family, a group of flowering plants.

General Description

Its common English-language name came about because of a resemblance to rue. Its seeds contain a high concentration of diverse beta-carboline alkaloids.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Zygophyllaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Harmel has been recorded in 10 countries and territories worldwide, including China, Spain, Israel, Kazakhstan, Morocco, and others.

Traditional Uses

Harmel has been traditionally used for digestive health, respiratory conditions, and urinary tract health, among other applications.

Digestive health.

  • Vermifuge
  • Colic

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Respiratory conditions.

  • Asthma

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Urinary tract health.

  • Diuretic

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Active Compounds

Phytochemical research has identified 24 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Abortifacient, Narcotic, Emetic, Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: China, Spain, Israel, Kazakhstan, Morocco, Pakistan, Turkey, Ukraine, United States, Uzbekistan.

Complete Use Records

CategoryCultural Context
LactogogueEgypt, India, Iran, Iraq
VermifugeElsewhere, Iraq, Italian, Pakistan
AlterativeEgypt, French, Iraq
AphrodisiacEgypt, India, Kurdistan
EmmenagogueGerman, India, Iraq
MalariaElsewhere, Iraq, Spanish
SudorificElsewhere, English, Iraq
AbortifacientElsewhere, India
AsthmaElsewhere, India
NarcoticElsewhere, Pakistan
RheumatismElsewhere, USSR
StimulantGerman, Turkey
StupefacientIndia, Iraq
Repellant(Insect)Elsewhere, Iraq
CalculusElsewhere
Cancer(Uterus)Europe
ColicElsewhere
DiureticIndia
DysmenorrheaElsewhere
EmeticElsewhere
EyesightElsewhere
FeverIndia
FumigantElsewhere
LaryngitisElsewhere
ParkinsonianismArabic
PediculicideElsewhere
PoisonMexico
UrogenitalIndia
HiccupElsewhere
ParkinsonismIraq

Complete Chemical Inventory

CompoundFormulaMW
9,14-DIHYDROXYOCTADECANOIC-ACIDC₁₈H₃₆O₄316.5 Da
ASH
CALCIUMCa40.08 Da
COPPERCu63.55 Da
DEOXYPEGANINEC₁₁H₁₂N₂172.23 Da
DEOXYVASICINONEC₁₁H₁₀N₂O186.21 Da
DIPEGENE
FATC₁₆H₃₂O₂256.42 Da
FIBER
HARMALINEC₁₃H₁₄N₂O214.26 Da
HARMALOLC₁₂H₁₂N₂O200.24 Da
HARMANC₁₂H₁₀N₂182.22 Da
HARMINEC₁₃H₁₂N₂O212.25 Da
ISOPEGANINE
PEGAMINEC₁₁H₁₂N₂O₂204.22 Da
PEGANINEC₁₁H₁₂N₂O188.23 Da
PEGANOLC₁₁H₁₂N₂O188.23 Da
PEGANONES
PHOSPHORUSP30.97376200 Da
PROTEIN
RUINE
VASCINONES
VASICINONEC₁₁H₁₀N₂O₂202.21 Da
WATERH₂O18.015 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources