Guarana

Botanical Overview

Guarana (Paullinia cupana) belongs to the Sapindaceae family. Limited but reliable traditional records indicate this plant has recognized medicinal applications in one or more healing traditions. This species belongs to the Sapindaceae family, a group of flowering plants.

General Description

Guaraná has large leaves and clusters of flowers, and is best known for the seeds from its beans, which are about the size of a coffee bean.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Sapindaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Guarana has been recorded in 10 countries and territories worldwide, including Belgium, Bolivia, Brazil, Colombia, Costa Rica, and others.

Traditional Uses

Guarana has been traditionally used for digestive health, pain and inflammation, and nervous system disorders, among other applications.

Digestive health.

  • Diarrhea

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Pain and inflammation.

  • Neuralgia

For pain and inflammation, preparations are applied both topically as compresses and taken internally. A warm poultice draws blood to the area and promotes healing, while internal preparations address systemic inflammation.

Nervous system disorders.

  • Nervine

Nervous system support involves taking the herb as a warm tea, often in the evening or before bed. The calming compounds interact with neurotransmitter systems to promote relaxation and restful sleep.

Active Compounds

Phytochemical research has identified 21 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Phenolic: antioxidant compounds that neutralize free radicals
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
  • Tannin: astringent compounds that tighten tissues and resist infection
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Belgium, Bolivia, Brazil, Colombia, Costa Rica, Ecuador, Guyana, Peru, United States, Venezuela.

Complete Use Records

CategoryCultural Context
CoffeeAmazon, Mexico
DiarrheaEnglish, Mexico
StimulantFrench, Mexico
AstringentEnglish
IntoxicantSouth America
NervineDutch
NeuralgiaSpanish
TonicGerman
MigraineItalian

Complete Chemical Inventory

CompoundFormulaMW
ADENINEC₅H₅N₅135.13 Da
ASH
CAFFEINEC₈H₁₀N₄O₂194.19 Da
CATECHOLC₆H₆O₂110.11 Da
CATECHUTANNIC-ACID
CHOLINEC₅H₁₄NO+104.17 Da
D-CATECHINC₁₅H₁₄O₆290.27 Da
FATC₁₆H₃₂O₂256.42 Da
GUANINEC₅H₅N₅O151.13 Da
GUARANINEC₈H₁₀N₄O₂194.19 Da
HYPOXANTHINEC₅H₄N₄O136.11 Da
MUCILAGE
PROTEIN
RESINC₁₅H₂₄204.35 Da
SAPONINSC₅₅H₈₆O₂₄1131.3 Da
STARCH
TANNIN
THEOBROMINEC₇H₈N₄O₂180.16 Da
THEOPHYLLINEC₇H₈N₄O₂180.16 Da
TIMBONINE
XANTHINEC₅H₄N₄O₂152.11 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources