Oleander

Botanical Overview

Oleander (Nerium oleander) is a flowering plant in the Apocynaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. The dogbane family (Apocynaceae) includes herbs, shrubs, vines, and trees with milky sap containing alkaloids and cardiac glycosides. The flowers are typically five-petaled and often showy with a tubular corolla. Many species in this family are highly toxic but also source of important cardiac medications.

General Description

It is the only species currently classified in the genus Nerium, belonging to subfamily Apocynoideae of the dogbane family Apocynaceae. It is so widely cultivated that no precise region of origin has been identified, though it is usually associated with the Mediterranean Basin.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Apocynaceae family is primarily tropical and subtropical. Notable medicinal members include:

Geographic Distribution

Oleander has been recorded in 10 countries and territories worldwide, including Australia, Spain, France, Greece, Israel, and others.

Traditional Uses

Oleander has been traditionally used for digestive health, skin and wound care, and urinary tract health, among other applications.

Digestive health.

  • Purgative

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Skin and wound care.

  • Skin
  • Psoriasis
  • Scabies
  • Sore
  • Eruption

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Urinary tract health.

  • Diuretic

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Flavonoid: antioxidant compounds that protect cells from oxidative damage
  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Toxicity warning: Contains cardiac glycosides. All parts are highly toxic. Traditional records: This plant has documented uses including Poison, Emetic, Purgative. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Australia, Spain, France, Greece, Israel, India, Italy, Portugal, Turkey, United States.

Complete Use Records

CategoryCultural Context
PoisonElsewhere, Haiti, Kurdistan, Mexico, Samoa, Turkey, Venezuela
CardiotonicElsewhere, Haiti, Iraq, Turkey
SkinDominican Republic, Elsewhere, Mexico
TumorLibya, Morocco, West Indies
CardiacHaiti, Mexico
DiureticElsewhere, Turkey
HomicideDominican Republic, Mexico
ParasiticideHaiti, Mexico
RaticideEurope, Mexico
RodenticideDominican Republic, Haiti
TonicMexico, Turkey
ApostemeEurope
AtheromaKurdistan
CarcinomaCuba
CornCuba
CyanogeneticUS
EmeticHaiti
FatalityTurkey
InsecticideElsewhere
Repellant(Insect)Venezuela
PsoriasisHaiti
PurgativeHaiti
ScabiesSpain
SoreArgentina
StimulantDominican Republic
WartVenezuela
WeaknessMalaya
EpitheliomaPuerto Rico
EruptionElsewhere
SternutatoryHaiti

Complete Chemical Inventory

CompoundFormulaMW
16-ANHYDRO-DEACETYL-NERIGOSIDE
9-D-HYDROXY-CIS-12-OCTADECANOIC-ACID
ADIGOSIDEC₃₅H₅₄O₉618.8 Da
ADYNERINC₃₀H₄₄O₇516.7 Da
ALKALOIDS
ALPHA-AMYRINC₃₀H₅₀O426.7 Da
BETA-SITOSTEROLC₂₉H₅₀O414.7 Da
BETULINC₃₀H₅₀O₂442.7 Da
BETULINIC-ACIDC₃₀H₄₈O₃456.7 Da
CAMPESTEROLC₂₈H₄₈O400.7 Da
CAOUTCHOUCC₅H₈68.12 Da
CAPRIC-ACIDC₁₀H₂₀O₂172.26 Da
CAPROIC-ACIDC₆H₁₂O₂116.16 Da
CAPRYLIC-ACIDC₈H₁₆O₂144.21 Da
CHOLINEC₅H₁₄NO+104.17 Da
CORNERIN
CORTENERIN
DEACETYLOLEANDRINC₃₀H₄₆O₈534.7 Da
DIACETYL-NERIGOSIDE
FATC₁₆H₃₂O₂256.42 Da
FOLIANDRINC₃₂H₄₈O₉576.7 Da
FOLINERINC₃₂H₄₈O₉576.7 Da
GENTIOBIOSYLOLEANDRINC₄₄H₆₈O₁₉901.0 Da
GITOXIGENINC₂₃H₃₄O₅390.5 Da
GLYCOSIDESC₂₉H₄₄O₁₂584.7 Da
HCNCHN27.025 Da
ISOQUERCITRINC₂₁H₂₀O₁₂464.4 Da
KAEMPFEROL-3-RHAMNOGLUCOSIDEC₂₇H₃₀O₁₅594.5 Da
LAURIC-ACIDC₁₂H₂₄O₂200.32 Da
LINOLEIC-ACIDC₁₈H₃₂O₂280.4 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources