Alfalfa

Also known as: Lucerne

Botanical Overview

Alfalfa (Medicago sativa subsp. sativa) is a flowering plant in the Fabaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. The legume family (Fabaceae) includes trees, shrubs, and herbs that produce pods (legumes) and form nitrogen-fixing root nodules through symbiosis with bacteria. The flowers are typically pea-shaped with five petals. This large family provides food staples, timber, and numerous medicinal species.

Family Context

The Fabaceae family is large and globally distributed. Notable medicinal members include:

Geographic Distribution

Alfalfa has been recorded in 10 countries and territories worldwide, including Afghanistan, Canada, Denmark, Spain, France, and others.

Traditional Uses

Alfalfa has been traditionally used for skin and wound care, urinary tract health, and pain and inflammation, among other applications.

Skin and wound care.

  • Boil

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Urinary tract health.

  • Gravel

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Pain and inflammation.

  • Arthritis
  • Anodyne

For pain and inflammation, preparations are applied both topically as compresses and taken internally. A warm poultice draws blood to the area and promotes healing, while internal preparations address systemic inflammation.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Flavonoid: antioxidant compounds that protect cells from oxidative damage
  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Emetic. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Afghanistan, Canada, Denmark, Spain, France, United Kingdom, Greece, Sweden, Turkey, United States.

Complete Use Records

CategoryCultural Context
ArthritisIraq, Kurdistan, Turkey
ScurvySpain, Turkey
BactericideElsewhere
BoilElsewhere
CancerUS
CyanogeneticUS
DepurativeChina
EmmenagogueElsewhere
GravelChina
LactagogueElsewhere
AnodyneChina
CardiotonicTurkey
DysuriaChina
EmeticChina
FeverChina
IntellectTurkey

Complete Chemical Inventory

CompoundFormulaMW
(-)-5'-METHOXYSATIVANC₁₈H₂₀O₅316.3 Da
(S)-N-(3-HYDROXYPROPYL)-AZETIDINE-CARBOXYLIC-ACID
10-METHOXY-MEDICARPIN
11,12-DIMETHOXY-7-HYDROXYCOUMESTIN
2-(4-HYDROXY-2-METHOXY-PHENYL)-6-METHOXY-BENZOFURAN-3-CARBOXYLIC-ACID
2-CARBOXYARABINITOLC₆H₁₂O₇196.16 Da
2-METHYL-PROPANOLC₄H₁₀O74.12 Da
3',4',5-TRIHYDROXY-7-METHOXY-FLAVONE
3',4',7-TRIHYDROXYFLAVONEC₁₅H₁₀O₅270.24 Da
3'-METHOXYCOUMESTROLC₁₆H₁₀O₆298.25 Da
3-BETA-GALACTOSIDASEC₆H₁₂O₆180.16 Da
3-METHYL-BUTANOLC₅H₁₂O88.15 Da
4',7-DIHYDROXYFLAVONEC₁₅H₁₀O₄254.24 Da
4'-METHOXYCOUMESTROLC₁₆H₁₀O₅282.25 Da
4'-O-METHYLCOUMESTROLC₁₆H₁₀O₅282.25 Da
4-AMINO-BUTYRIC-ACID
7,5'-DIHYDROXY-2',3',4'-TRIMETHOXYISOFLAVANC₁₈H₂₀O₆332.3 Da
7-HYDROXY-2',3',4-TRIMETHOXYISOFLAVAN
8-METHOXYCOUMESTROLC₁₆H₁₀O₆298.25 Da
9-O-METHYLCOUMESTROLC₁₆H₁₀O₅282.25 Da
ACETONEC₃H₆O58.08 Da
ADENINEC₅H₅N₅135.13 Da
ADENOSINEC₁₀H₁₃N₅O₄267.24 Da
AESCULETINC₉H₆O₄178.14 Da
ALFALFONE
ALFALONEC₁₇H₁₄O₅298.29 Da
ALPHA-CRYPTOXANTHIN
ALPHA-SPINASTEROLC₂₉H₄₈O412.7 Da
ALPHA-TOCOPHEROLC₂₉H₅₀O₂430.7 Da
ALUMINUMAl26.981538 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources