Peyote

Botanical Overview

Peyote (Lophophora williamsii) is a flowering plant in the Cactaceae family. The traditional uses of this species reflect its genuine medicinal value, validated by generations of practical experience. The cactus family (Cactaceae) includes succulent plants with thick, fleshy stems modified for water storage and spines instead of leaves. The flowers are typically large, showy, and short-lived with numerous petals and stamens. Many species produce alkaloids and have traditional medicinal uses.

General Description

Peyote is a Spanish word derived from the Nahuatl peyōtl, meaning “caterpillar cocoon”, from a root peyōni, “to glisten”.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Cactaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Peyote has been recorded in 10 countries and territories worldwide, including Belgium, Germany, Spain, France, Japan, and others.

Traditional Uses

Peyote has been traditionally used for pain and inflammation, nervous system disorders, and fever management, among other applications.

Pain and inflammation.

  • Ache(Head)
  • Anodyne
  • Arthritis
  • Rheumatism

For pain and inflammation, preparations are applied both topically as compresses and taken internally. A warm poultice draws blood to the area and promotes healing, while internal preparations address systemic inflammation.

Nervous system disorders.

  • Sedative
  • Narcotic

Nervous system support involves taking the herb as a warm tea, often in the evening or before bed. The calming compounds interact with neurotransmitter systems to promote relaxation and restful sleep.

Fever management.

  • Fever

Febrifuge preparations are typically administered as hot teas to induce perspiration, which helps the body regulate temperature. The patient is kept warm and encouraged to rest while the herb promotes sweating.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Terpene: aromatic compounds with anti-inflammatory and antimicrobial properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Narcotic, Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Belgium, Germany, Spain, France, Japan, Latvia, Mexico, Panama, United States, Unknown.

Complete Use Records

CategoryCultural Context
HallucinogenMexico, Mexico(Huichol), US(Blackfoot)
PsychedelicAmerindian, US
SedativeElsewhere, Mexico
Ache(Back)Mexico
Ache(Head)Mexico(Kickapoo)
AnodyneMexico
CardiotonicMexico
FeverMexico
IntoxicantUS
LactogogueMexico
NarcoticMexico
PoisonMexico
PopisonMexico
ReligionMexico(Huichol)
SunstrokeMexico(Kickapoo)
TonicMexico
CornUS(Arapaho)
ArthritisMexico(Kickapoo)
RheumatismMexico

Complete Chemical Inventory

CompoundFormulaMW
3,4-DIMETHOXYPHENETHYLEMINE
ALKALOIDS
ANHALAMINEC₁₁H₁₅NO₃209.24 Da
ANHALIDINEC₁₂H₁₇NO₃223.27 Da
ANHALININEC₁₂H₁₇NO₃223.27 Da
ANHALONIDINEC₁₂H₁₇NO₃223.27 Da
ANHALONINEC₁₂H₁₅NO₃221.25 Da
ANHALOTINE
CANDICINEC₁₁H₁₈NO+180.27 Da
DEMETHYL-MESCALINE
HORDENINEC₁₀H₁₅NO165.23 Da
LOPHOPHORINEC₁₃H₁₇NO₃235.28 Da
LOPHOTINE
MESCALINEC₁₁H₁₇NO₃211.26 Da
MESCALINE-CITRIMIDE
MESCALINE-ISOCITRIMIDE-LACTONE
MESCALINE-MALEIMIDE
MESCALINE-MALIMIDE
MESCALINE-SUCCINIMIDE
MESCALOTAM
N-ACETYL-3-DEMETHYLMESCALINE
N-ACETYL-ANHALAMINE
N-ACETYL-ANHALONINE
N-ACETYLMESCALINEC₁₃H₁₉NO₄253.29 Da
N-FORMYL-3-DEMETHYLMESCALINE
N-FORMYL-ANHALAMINE
N-FORMYL-ANHALONIDINE
N-FORMYL-ANHALONINE
N-FORMYL-MESCALINE
N-FORMYL-O-METHYL-ANHALONIDINE

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources