Prickly Lettuce

Botanical Overview

Prickly Lettuce (Lactuca scariola) belongs to the Asteraceae family. While not among the most extensively documented medicinal plants, this species has recorded uses that warrant attention from researchers and practitioners. The daisy family (Asteraceae) is one of the largest plant families, characterized by composite flower heads (capitula) that contain many small florets surrounded by bracts. Plants range from tiny alpine herbs to large tropical trees. The family includes many medicinally important species with bitter compounds and essential oils.

General Description

It has a slightly fetid odor and is commonly considered a weed of orchards, roadsides and field crops. It is the closest wild relative of cultivated lettuce.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Asteraceae family is extremely large and diverse. Notable medicinal members include:

Geographic Distribution

Prickly Lettuce has been recorded in 10 countries and territories worldwide, including Austria, Canada, Germany, France, Italy, and others.

Traditional Uses

Prickly Lettuce has been traditionally used for skin and wound care, urinary tract health, and nervous system disorders, among other applications.

Skin and wound care.

  • Sore

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Urinary tract health.

  • Diuretic

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Nervous system disorders.

  • Sedative
  • Nervine
  • Spasm

Nervous system support involves taking the herb as a warm tea, often in the evening or before bed. The calming compounds interact with neurotransmitter systems to promote relaxation and restful sleep.

Active Compounds

Phytochemical research has identified 26 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Austria, Canada, Germany, France, Italy, Japan, South Korea, Luxembourg, United States, Unknown.

Complete Use Records

CategoryCultural Context
SedativeGerman, Iraq, US(Colonial)
DiureticEnglish, US
PoisonItalian, US
AntiphlogisticElsewhere
ChafeUS
EmollientFrench
LactogogueUS
NervineUS(Colonial)
SoreUS
TonicUS(Colonial)
MedicineUS(Appalachia)
Skin lotionUS
SpasmDutch

Complete Chemical Inventory

CompoundFormulaMW
8-DEOXYLACTUCINC₁₅H₁₆O₄260.28 Da
ALPHA-TOCOPHEROLC₂₉H₅₀O₂430.7 Da
ARACHIDIC-ACIDC₂₀H₄₀O₂312.5 Da
BETA-AMYRINC₃₀H₅₀O426.7 Da
BETA-LACTUCEROL
BETA-SITOSTEROLC₂₉H₅₀O414.7 Da
CAOUTCHOUCC₅H₈68.12 Da
CAPROIC-ACIDC₆H₁₂O₂116.16 Da
CITRIC-ACIDC₆H₈O₇192.12 Da
FATC₁₆H₃₂O₂256.42 Da
GAMMA-LACTUCEROL
GERMANICOLC₃₀H₅₀O426.7 Da
HYOSCYAMINEC₁₇H₂₃NO₃289.4 Da
INULIN
LACTUCINC₁₅H₁₆O₅276.28 Da
LACTUCOPICRINC₂₃H₂₂O₇410.4 Da
LINOLEIC-ACIDC₁₈H₃₂O₂280.4 Da
MALIC-ACIDC₄H₆O₅134.09 Da
MANNITOLC₆H₁₄O₆182.17 Da
OLEIC-ACIDC₁₈H₃₄O₂282.5 Da
OXALIC-ACIDC₂H₂O₄90.03 Da
PALMITIC-ACIDC₁₆H₃₂O₂256.42 Da
RESINC₁₅H₂₄204.35 Da
SQUALENEC₃₀H₅₀410.7 Da
STEARIC-ACIDC₁₈H₃₆O₂284.5 Da
TARAXASTEROLC₃₀H₅₀O426.7 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources