Goldenseal

Botanical Overview

Goldenseal (Hydrastis canadensis) is a flowering plant in the Ranunculaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. The buttercup family (Ranunculaceae) includes herbs with alternate or basal leaves and showy flowers with numerous stamens and pistils. Many species contain protoanemonin and other acrid compounds that cause skin irritation. Despite their toxicity, several species have been used in traditional medicine for pain and inflammation.

General Description

It may be distinguished by its thick, yellow knotted rootstock. The stem is purplish and hairy above ground and yellow below ground where it connects to the yellow rhizome. Goldenseal reproduces both clonally through the rhizome and sexually, with clonal division more frequent than asexual reproduction. It takes between 4 and 5 years for a plant to reach sexual maturity, i. e. the point at which it produces flowers. Plants in the first stage, when the seed erupts and cotyledons emerge, can remain in this state one or more years. The second vegetative stage occurs during years two and three and is characterized by the development of a single leaf and absence of a well developed stem. Finally, the third stage is reproductive, at which point flowering and fruiting occurs. This last stage takes between 4 and 5 years to develop.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Ranunculaceae family is widely distributed in temperate regions. Notable medicinal members include:

Geographic Distribution

Goldenseal has been recorded in 7 countries and territories worldwide, including Canada, China, Netherlands, Norway, Sweden, and others.

Traditional Uses

Goldenseal has been traditionally used for respiratory conditions, skin and wound care, and urinary tract health, among other applications.

Respiratory conditions.

  • Catarrh

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Skin and wound care.

  • Wound
  • Sore

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Urinary tract health.

  • Diuretic

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Canada, China, Netherlands, Norway, Sweden, United States, Unknown.

Complete Use Records

CategoryCultural Context
TonicTurkey, US, US(Appalachia)
CancerAustralia, US(Cherokee)
EyeUS(Amerindian), US(Appalachia)
AlterativeTurkey
AntisepticTurkey
AstringentUS
CatarrhUS(Appalachia)
CicatrizantUS
DiureticTurkey
EnterorrhagiaTurkey
HemostatTurkey
HemostaticUS
LiverUS
MetrorrhagiaUS
Mucous MembraneUS
StomatitisUS(Colonial)
UterotonicTurkey
WoundUS
DetergentTurkey
HemorrhoidsUS
PoisonUS
SoreUS(Appalachia)
AntiperiodicUS
AperientTurkey
ApertifUS(Appalachia)
MalariaTurkey
MedicineUS(Appalachia)
StomachUS
Repellant(Insect)US(Cherokee)

Complete Chemical Inventory

CompoundFormulaMW
(+)-CANADINEC₂₀H₂₁NO₄339.4 Da
(-)-ALPHA-HYDRASTINEC₂₁H₂₁NO₆383.4 Da
(-)-CANADINEC₂₀H₂₁NO₄339.4 Da
5-HYDROXYTETRAHYDROBERBERINE
ALKALOIDS
ALPHA-HYDRASTINEC₂₁H₂₁NO₆383.4 Da
ALUMINUMAl26.981538 Da
ASCORBIC-ACIDC₆H₈O₆176.12 Da
ASH
BERBERASTINEC₂₀H₁₈NO₅+352.4 Da
BERBERINEC₂₀H₁₈NO₄+336.4 Da
BETA-CAROTENEC₄₀H₅₆536.9 Da
BETA-HYDRASTINEC₂₁H₂₁NO₆383.4 Da
CALCIUMCa40.08 Da
CANADALINEC₂₁H₂₃NO₅369.4 Da
CANADINEC₂₀H₂₁NO₄339.4 Da
CANDALINE
CARBOHYDRATES
CHLOROGENIC-ACIDC₁₆H₁₈O₉354.31 Da
CHROMIUMCr51.996 Da
COBALTCo58.93319 Da
CORYPALMINEC₂₀H₂₃NO₄341.4 Da
D-FRUCTOSEC₆H₁₂O₆180.16 Da
D-GALACTOSEC₆H₁₂O₆180.16 Da
D-GLUCOSEC₆H₁₂O₆180.16 Da
FATC₁₆H₃₂O₂256.42 Da
FIBER
FIBER(CRUDE)
FIBER(DIETARY)
HYDRASTIDINE

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources