Manchineel

Botanical Overview

Manchineel (Hippomane mancinella) is a flowering plant in the Euphorbiaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. The spurge family (Euphorbiaceae) includes an extremely diverse group of plants ranging from small herbs to large trees, many with milky sap that can be irritating or toxic. The flowers are typically small and unisexual, often arranged in distinctive inflorescences. Many species contain diterpene esters and other bioactive compounds.

General Description

Its native range stretches from tropical southern North America to northern South America.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Euphorbiaceae family is large and globally distributed. Notable medicinal members include:

Geographic Distribution

Manchineel has been recorded in 10 countries and territories worldwide, including Colombia, Costa Rica, Curacao, Ecuador, Guadeloupe, and others.

Traditional Uses

Manchineel has been traditionally used for digestive health, urinary tract health, and reproductive health, among other applications.

Digestive health.

  • Vermifuge

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Urinary tract health.

  • Diuretic

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Reproductive health.

  • Syphilis
  • Venereal

In traditional contexts, reproductive health applications typically involve internal preparations such as teas or decoctions. The herb may be taken at specific times during the menstrual cycle.

Active Compounds

Phytochemical research has identified 6 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Poison, Emetic. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Colombia, Costa Rica, Curacao, Ecuador, Guadeloupe, Saint Kitts, Martinique, Mexico, Puerto Rico, United States.

Complete Use Records

CategoryCultural Context
PoisonDutch, Elsewhere, Guatemala, Haiti, Mexico, US(Florida), Venezuela
ArrowElsewhere, Guatemala, Mexico
CatharticElsewhere, French, Haiti
DiureticDominican Republic, Elsewhere
DropsyHaiti, Mexico
EmeticEnglish, Mexico
Poison(Arrow)Elsewhere, Panama(Choco)
SyphilisHaiti, Spanish
TetanusCuba, Haiti
VesicantElsewhere, Guatemala
FatalityElsewhere
InfectionCuba
PiscicideElsewhere
VermifugeGuiana
WartCuba
DermatitogenicWest Indies
CancerParaguay
DiaphoreticHaiti
HomeopathyGerman
HomicideMexico
VenerealMexico

Complete Chemical Inventory

CompoundFormulaMW
12-DEOXY-5-HYDROXYPHORBOL-6GAMMA,7ALPHA-OXIDE
HIPPOMANINS
MANCINELLINC₃₆H₅₂O₈612.8 Da
PHLORACETOPHENONE-2,4-DIMETHYLETHER
PHYSOSTIGMINEC₁₅H₂₁N₃O₂275.35 Da
SAPOGENIN

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources