Botanical Overview
Boneset (Eupatorium perfoliatum) is a flowering plant in the Asteraceae family. Traditional medicine systems have documented several valuable applications for this species, supported by its observed therapeutic effects. The daisy family (Asteraceae) is one of the largest plant families, characterized by composite flower heads (capitula) that contain many small florets surrounded by bracts. Plants range from tiny alpine herbs to large tropical trees. The family includes many medicinally important species with bitter compounds and essential oils.

General Description
It is a common native to the Eastern United States and Canada, widespread from Nova Scotia to Florida, west as far as Texas, Nebraska, the Dakotas, and Manitoba. It is also called agueweed, feverwort, or sweating-plant. In herbal medicine, the plant is a diaphoretic, or an agent to cause sweating. It was introduced to American colonists by natives who used the plant for breaking fevers by means of heavy sweating, and commonly used to treat fever by the African-American population of the southern United States. The name “boneset” comes from the use of the plant to treat dengue fever, which is also called “break-bone fever. " It is nearly always found in low, wet areas.
Family Context
The Asteraceae family is extremely large and diverse. Notable medicinal members include:
- Yarrow — 63 documented uses
- Gobo — 63 documented uses
- Mugwort — 55 documented uses
- Sunflower — 52 documented uses
Geographic Distribution
Boneset has been recorded in 10 countries and territories worldwide, including Austria, Belgium, Brazil, Canada, Colombia, and others.
Traditional Uses
Boneset has been traditionally used for digestive health, respiratory conditions, and pain and inflammation, among other applications.
Digestive health.
- Laxative
- Vermifuge
- Stomachic
For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.
Respiratory conditions.
- Cold
- Cough
- Expectorant
Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.
Pain and inflammation.
- Anodyne
For pain and inflammation, preparations are applied both topically as compresses and taken internally. A warm poultice draws blood to the area and promotes healing, while internal preparations address systemic inflammation.
Active Compounds
Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).
The identified compounds include the following categories:
- Flavonoid: antioxidant compounds that protect cells from oxidative damage