Coca

Botanical Overview

Coca (Erythroxylum novogranatense var. truxillense) is a species in the Erythroxylaceae family. The coca family (Erythroxylaceae) includes tropical shrubs and small trees with alternate leaves and small flowers. The plants produce alkaloids concentrated in the leaves, most notably cocaine and related tropane alkaloids. Species in this family have a long history of traditional stimulant and medicinal use in South America. Although comprehensive ethnobotanical records are limited, phytochemical studies have identified 27 compounds in this species, suggesting potential medicinal value.

Family Context

The Erythroxylaceae family is primarily neotropical. Notable medicinal members include:

Geographic Distribution

Coca has been recorded in 6 countries and territories worldwide, including Brazil, Colombia, Ecuador, Peru, United States, and others.

Active Compounds

Phytochemical research has identified 27 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Flavonoid: antioxidant compounds that protect cells from oxidative damage
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities

Research Status

Although this species has documented phytochemical constituents, its ethnobotanical and clinical documentation remains incomplete. The limited documentation available for this species represents an opportunity for ethnobotanical research.

ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Brazil, Colombia, Ecuador, Peru, United States, Unknown.

Complete Chemical Inventory

CompoundFormulaMW
(+)-PSEUDOCOCAINEC₁₇H₂₁NO₄303.35 Da
ALPHA-TRUXILLINEC₃₈H₄₆N₂O₈658.8 Da
BETA-COCAINE
BETA-TRUXILLINEC₃₈H₄₆N₂O₈658.8 Da
CALCIUMCa40.08 Da
CINNAMOYLCOCAINEC₁₉H₂₃NO₄329.4 Da
COCAINEC₁₇H₂₁NO₄303.35 Da
COPPERCu63.55 Da
CUSCOHYDRINE
CUSKHYGRINEC₁₃H₂₄N₂O224.34 Da
HYGRINEC₈H₁₅NO141.21 Da
HYGROLINEC₈H₁₇NO143.23 Da
IRONFe55.84 Da
KAEMPFEROL-3-O-ARABINOSIDEC₂₀H₁₈O₁₀418.3 Da
KAEMPFEROL-3-O-GLUCOSIDEC₂₁H₂₀O₁₁448.4 Da
KAEMPFEROL-3-O-RUTINOSIDEC₂₇H₃₀O₁₅594.5 Da
MAGNESIUMMg24.305 Da
MANGANESEMn54.93804 Da
OMBUIN-3-O-RUTINOSIDEC₂₉H₃₄O₁₆638.6 Da
POTASSIUMK39.0983 Da
QUERCETIN-3-O-ARABINOSIDEC₂₀H₁₈O₁₁434.3 Da
QUERCETIN-3-O-GLUCOSIDEC₂₁H₂₀O₁₂464.4 Da
QUERCETIN-3-O-RUTINOSIDEC₂₇H₃₀O₁₆610.5 Da
QUERCETIN-3-O-TRIGLYCOSIDE
TROPACOCAINEC₁₅H₁₉NO₂245.32 Da
WATERH₂O18.015 Da
ZINCZn65.4 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources