Coca

Botanical Overview

Coca (Erythroxylum coca var. coca) is a flowering plant in the Erythroxylaceae family. Traditional medicine systems have documented several valuable applications for this species, supported by its observed therapeutic effects. The coca family (Erythroxylaceae) includes tropical shrubs and small trees with alternate leaves and small flowers. The plants produce alkaloids concentrated in the leaves, most notably cocaine and related tropane alkaloids. Species in this family have a long history of traditional stimulant and medicinal use in South America.

Family Context

The Erythroxylaceae family is primarily neotropical. Notable medicinal members include:

Geographic Distribution

Coca has been recorded in 7 countries and territories worldwide, including Bolivia, Colombia, Costa Rica, Ecuador, Peru, and others.

Traditional Uses

Coca has been traditionally used for digestive health, respiratory conditions, and urinary tract health, among other applications.

Digestive health.

  • Carminative

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Respiratory conditions.

  • Asthma

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Urinary tract health.

  • Diuretic
  • Edema

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Narcotic, Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Bolivia, Colombia, Costa Rica, Ecuador, Peru, United States, Unknown.

Complete Use Records

CategoryCultural Context
MasticatoryAmerindian, Colombia(Cubeo), Elsewhere, India
NarcoticColombia(Cubeo), Ecuador, Elsewhere, Turkey
StimulantElsewhere, India, Peru, Turkey
AnestheticElsewhere, Europe, India
HungerAmerindian, Brazil(Maku), Colombia(Cubeo)
AsthmaAmerindian, Europe
HallucinogenEcuador(Jivaro), Peru
RheumatismAmerindian, Europe
AperientAmerindian
AstringentIndia
CarminativeAmerindian
DepressionEurope
DepurativeElsewhere
DigestiveAmerindian
DiureticAmerindian
EdemaAmerindian
EpistaxisAmerindian
FractureAmerindian
HoarsenessAmerindian
LongevityAmerindian
MydriaticIndia
NervousnessEurope
NeurastheniaEurope
NeuritisIndia
PoisonSouth America
PsychedelicAmerindian
SpleenAmerindian
ThirstAmerindian
ThroatEurope
Ache(Head)Amerindian

Complete Chemical Inventory

CompoundFormulaMW
(-)-DIHYDROCUSCOHYGRINEC₁₃H₂₆N₂O226.36 Da
1-HEXANOLC₆H₁₄O102.17 Da
6-PHOSPHOGLUCONATE-DEHYDROGENASE
ACONITASE
ADENYLATE-KINASE
ALANINE-AMINOTRANSFERASEC₁₁H₁₆N₂O₆272.25 Da
ALCOHOL-DEHYDROGENASEC₄₃H₆₂N₇O₁₈P₃S-₄1090.0 Da
ALKALINE-PHOSPHATASEC₂₁H₃₆N₈O₆496.6 Da
ALKALOIDS
ALPHA-TRUXILLINEC₃₈H₄₆N₂O₈658.8 Da
ALPHA-TRUXINIC-ACID
ALUMINUMAl26.981538 Da
ASCORBIC-ACIDC₆H₈O₆176.12 Da
ASH
BARIUMBa137.33 Da
BENZOYLACGONINE
BENZOYLECGONINEC₁₆H₁₉NO₄289.33 Da
BENZOYLTROPEINC₁₅H₁₉NO₂245.32 Da
BENZOYLTROPINEC₁₅H₁₉NO₂245.32 Da
BETA-AMYRINC₃₀H₅₀O426.7 Da
BETA-CAROTENEC₄₀H₅₆536.9 Da
BETA-COCAINE
BETA-TRUXILLINEC₃₈H₄₆N₂O₈658.8 Da
BETA-TRUXINIC-ACID
BIOTINC₁₀H₁₆N₂O₃S244.31 Da
BORONB10.81 Da
CAFFEIC-ACIDC₉H₈O₄180.16 Da
CALCIUMCa40.08 Da
CARBOHYDRATES
CEROTIC-ACIDC₂₆H₅₂O₂396.7 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources