Purple Foxglove

Botanical Overview

Purple Foxglove (Digitalis purpurea) is a flowering plant in the Scrophulariaceae family. The traditional uses of this species reflect its genuine medicinal value, validated by generations of practical experience. The figwort family (Scrophulariaceae) includes herbs and shrubs with alternate or opposite leaves and two-lipped, often showy flowers. The fruits are typically capsules with many small seeds. Many species contain iridoid glycosides and cardiac glycosides with medicinal properties.

General Description

It has also naturalized in parts of North America, as well as some other temperate regions. The plant is a popular garden subject, with many cultivars available. It is the original source of the heart medicine digoxin. This biennial plant grows as a rosette of leaves in the first year after sowing, before flowering and then dying in the second year. It generally produces enough seeds so that new plants will continue to grow in a garden setting.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Scrophulariaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Purple Foxglove has been recorded in 10 countries and territories worldwide, including Belgium, Canada, Germany, France, United Kingdom, and others.

Traditional Uses

Purple Foxglove has been traditionally used for respiratory conditions, urinary tract health, and pain and inflammation, among other applications.

Respiratory conditions.

  • Asthma

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Urinary tract health.

  • Diuretic
  • Edema

Urinary tract applications typically involve drinking the herb as a mild tea, which increases urine production and helps flush the urinary system. It may be combined with other demulcent herbs to soothe irritated tissues.

Pain and inflammation.

  • Neuralgia

For pain and inflammation, preparations are applied both topically as compresses and taken internally. A warm poultice draws blood to the area and promotes healing, while internal preparations address systemic inflammation.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Flavonoid: antioxidant compounds that protect cells from oxidative damage
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Toxicity warning: Contains digitoxin and other cardiac glycosides. Narrow therapeutic index. Traditional records: This plant has documented uses including Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Belgium, Canada, Germany, France, United Kingdom, Netherlands, Norway, Portugal, Sweden, United States.

Complete Use Records

CategoryCultural Context
CardiotonicIndia, Japan*, Kurdistan, Spain, Turkey, US
PoisonElsewhere, Iraq, Turkey
HeartElsewhere, Mexico
TonicNepal, Turkey
BactericideElsewhere
DiureticTurkey
DropsyElsewhere
FatalityUS
FeverUS
InsanityUS
NeuralgiaUS
PalpitationUS
SedativeTurkey
Stimulant(Cardio)Nepal
Tumor(Abdomen)Uk(Wales)
AsthmaUS
EdemaTurkey
RenitisElsewhere
StimulantTurkey

Complete Chemical Inventory

CompoundFormulaMW
1-METHOXY-2-HYDROXY-3-METHYL-ANTHRAQUINONE
1-METHOXY-2-METHYL-ANTHRAQUINONEC₁₆H₁₂O₃252.26 Da
14ALPHA-DIGIPRONIN
16-ACETYLGITOXINC₄₃H₆₆O₁₅823.0 Da
3-METHOXY-2-METHYL-ANTHRAQUINONE
3-METHYL-ALIZARIN
3-METHYLPURPURIN
4-HYDROXYDIGITOLUTEIN
6,8-DIHYDROXYMYRICETIN
ACETIC-ACIDC₂H₄O₂60.05 Da
ACETYL-CHOLINE
APIGENINC₁₅H₁₀O₅270.24 Da
APIGENIN-GLUCOSYLAPIOSIDE
BENZOIC-ACIDC₇H₆O₂122.12 Da
CAFFEIC-ACIDC₉H₈O₄180.16 Da
CARDEONOLIDES
CEROTIC-ACIDC₂₆H₅₂O₂396.7 Da
CHLOROGENIC-ACIDC₁₆H₁₈O₉354.31 Da
CHOLINEC₅H₁₄NO+104.17 Da
CITRIC-ACIDC₆H₈O₇192.12 Da
CYANIDIN-3,5-DIGLUCOSIDEC₂₇H₃₁O₁₆+611.5 Da
DEGALACTOTIGOGENIN
DESGLUCODIGITONINC₅₀H₈₂O₂₄1067.2 Da
DIGACETENIN
DIGALOGENINC₂₇H₄₄O₄432.6 Da
DIGALONINC₅₆H₉₂O₂₈1213.3 Da
DIGICITRINC₂₁H₂₂O₁₀434.4 Da
DIGIFOLEINC₂₈H₄₀O₈504.6 Da
DIGIFUCOCELLOBIOSIDE
DIGININC₂₈H₄₀O₇488.6 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources