Huang-Lia

Also known as: Huang-Lian, Huang-Lien, Japanese Goldthread

Botanical Overview

Huang-Lia (Coptis japonica) belongs to the Ranunculaceae family. While not among the most extensively documented medicinal plants, this species has recorded uses that warrant attention from researchers and practitioners. The buttercup family (Ranunculaceae) includes herbs with alternate or basal leaves and showy flowers with numerous stamens and pistils. Many species contain protoanemonin and other acrid compounds that cause skin irritation. Despite their toxicity, several species have been used in traditional medicine for pain and inflammation.

General Description

In Asia it is grown for medicinal purposes, with the main alkaloid being berberine.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Ranunculaceae family is widely distributed in temperate regions. Notable medicinal members include:

Geographic Distribution

Huang-Lia has been recorded in 6 countries and territories worldwide, including Belgium, Japan, South Korea, Taiwan, United States, and others.

Traditional Uses

Huang-Lia has been traditionally used for digestive health, nervous system disorders, and metabolic and nutritional health.

Digestive health.

  • Stomachic

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Nervous system disorders.

  • Sedative

Nervous system support involves taking the herb as a warm tea, often in the evening or before bed. The calming compounds interact with neurotransmitter systems to promote relaxation and restful sleep.

Metabolic and nutritional health.

  • Tonic

Metabolic applications include consuming the plant as a food, fresh juice, or herbal infusion. Regular use supports the body’s natural metabolic processes and nutritional status.

Active Compounds

Phytochemical research has identified 19 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Belgium, Japan, South Korea, Taiwan, United States, Unknown.

Complete Use Records

CategoryCultural Context
StomachicJapan, Japan*
AntiphlogisticJapan*
Bitter-PrincipleJapan*
SedativeJapan*
TonicJapan
IntestineJapan

Complete Chemical Inventory

CompoundFormulaMW
ARSENICAs74.92159 Da
BERBERINEC₂₀H₁₈NO₄+336.4 Da
CALCIUMCa40.08 Da
COLUMBAMINEC₂₀H₂₀NO₄+338.4 Da
COPPERCu63.55 Da
COPTISIDE-I
COPTISIDE-II
COPTISINEC₁₉H₁₄NO₄+320.3 Da
FERULIC-ACIDC₁₀H₁₀O₄194.18 Da
IRONFe55.84 Da
JATEORRHIZINEC₂₀H₂₀NO₄+338.4 Da
MAGNESIUMMg24.305 Da
MAGNOFLORINEC₂₀H₂₄NO₄+342.4 Da
MANGANESEMn54.93804 Da
PALMATINEC₂₁H₂₂NO₄+352.4 Da
POTASSIUMK39.0983 Da
SODIUMNa22.9897693 Da
WORENINEC₂₀H₁₆NO₄+334.3 Da
ZINCZn65.4 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources