Forskohl's Coleus

Botanical Overview

Forskohl’s Coleus (Coleus barbatus) is a species in the Lamiaceae family. The mint family (Lamiaceae) includes aromatic herbs and shrubs with square stems, opposite leaves, and two-lipped flowers. Many species produce essential oils in glandular trichomes on their leaves and stems. This family is one of the most important sources of culinary and medicinal herbs worldwide. Although comprehensive ethnobotanical records are limited, phytochemical studies have identified 30 compounds in this species, suggesting potential medicinal value.

General Description

It is known by the common name woolly plectranthus. It produces forskolin, an extract useful for pharmaceutical preparations and research in cell biology.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Lamiaceae family is large and widely distributed. Notable medicinal members include:

  • Basil — 86 documented uses
  • Rosemary — 60 documented uses
  • Agbo — 54 documented uses
  • Sage — 49 documented uses

Geographic Distribution

Forskohl’s Coleus has been recorded in 10 countries and territories worldwide, including Brazil, Congo (DRC), Ethiopia, India, Kenya, and others.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

Research Status

Although this species has documented phytochemical constituents, its ethnobotanical and clinical documentation remains incomplete. Systematic pharmacological studies are needed to validate the traditional uses attributed to this species.

ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Brazil, Congo (DRC), Ethiopia, India, Kenya, Sri Lanka, New Zealand, Portugal, Tanzania, South Africa.

Complete Chemical Inventory

CompoundFormulaMW
(+)-FERRUGINOLC₂₀H₃₀O286.5 Da
1,9-DIDEOXY-7-DEACETYL-FORSKOHLIN
1,9-DIDEOXYCOLEONOL
1,9-DIDEOXYFORSKOHLIN
1,9-DIDEOXYFORSKOLINC₂₂H₃₄O₅378.5 Da
1-ACETOXY-COLEOSOL
1-ACETYL-FORSKOLIN
1-ALPHA-6-BETA-7-ALPHA-TRIACETYL-COLEONOL-B
1-DEOXYFORSKOLINC₂₂H₃₄O₆394.5 Da
16(R)-PLECTRINON-A
20-DEOXOCARNOSOLC₂₀H₂₈O₃316.4 Da
3BETA-HYDROXY-3-DEOXYBARBATUSIN
6-ALPHA-HYDROXY-CARNOSOL
6-BETA-7-BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
6BETA,7BETA,9ALPHA-TRIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
6BETA-HYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
6BETA-HYDROXY-CARNOSOL
7-BETA-ACETOXY-1-ALPHA-6-BETA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
7-BETA-ACETOXY-6-BETA-HYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
7BETA-ACETOXY-6BETA,9ALPHA-DIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
8,13-EPOXY-LABD-14-EN-11-ONE
9-ALPHA-HYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
9-DEOXYFORSKOHLIN
ACETYL-FORSKOLIN
ALLYL-ROYLEANONE
ALPHA-COPAENEC₁₅H₂₄204.35 Da
ALPHA-CURCUMENEC₁₅H₂₂202.33 Da
ALPHA-HUMULENEC₁₅H₂₄204.35 Da
ALPHA-IONONEC₁₃H₂₀O192.30 Da
ALPHA-PHELLANDRENEC₁₀H₁₆136.23 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources