Quinine

Botanical Overview

Quinine (Cinchona spp) is a species in the Rubiaceae family. The coffee family (Rubiaceae) includes trees, shrubs, and herbs with opposite leaves and interpetiolar stipules. The flowers are typically tubular with four or five petals. The family includes coffee (Coffea), quinine-producing Cinchona, and numerous other medicinal species with alkaloid constituents. Although comprehensive ethnobotanical records are limited, phytochemical studies have identified 30 compounds in this species, suggesting potential medicinal value.

Family Context

The Rubiaceae family is large and primarily tropical. Notable medicinal members include:

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Phenolic: antioxidant compounds that neutralize free radicals
  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities

Research Status

Although this species has documented phytochemical constituents, its ethnobotanical and clinical documentation remains incomplete. Additional phytochemical investigation could identify novel bioactive compounds in this plant.

ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Complete Chemical Inventory

CompoundFormulaMW
(-)-EPICATECHINC₁₅H₁₄O₆290.27 Da
10-METHOXYCINCHONAMINE
3-ALPHA,17-ALPHA-CINCHOPHYLLINE
3-ALPHA,17-BETA-CINCHOPHYLLINEC₃₁H₃₆N₄O₂496.6 Da
3-EPIQUINAMINEC₁₉H₂₄N₂O₂312.4 Da
ALIZARIN-2-METHYL-ETHERC₁₅H₁₀O₄254.24 Da
ALKALOIDS
ALPHA-QUINOVINE
ARICINEC₂₂H₂₆N₂O₄382.5 Da
ASH
BETA-QUINOVINE
BETA-SITOSTEROLC₂₉H₅₀O414.7 Da
CAFFEIC-ACIDC₉H₈O₄180.16 Da
CATECHIN-TANNINS
CATECHOL-TANNINS
CINCHOFULVIC-ACID
CINCHOLIC-ACID-BETA-D-QUINOVOSIDE
CINCHONAIN-IAC₂₄H₂₀O₉452.4 Da
CINCHONAIN-IBC₂₄H₂₀O₉452.4 Da
CINCHONAIN-ICC₂₄H₂₀O₉452.4 Da
CINCHONAIN-IDC₂₄H₂₀O₉452.4 Da
CINCHONAIN-IIAC₃₉H₃₂O₁₅740.7 Da
CINCHONAIN-IIBC₃₉H₃₂O₁₅740.7 Da
CINCHONIDINEC₁₉H₂₂N₂O294.4 Da
CINCHONINEC₁₉H₂₂N₂O294.4 Da
CINCHONININE
CINCHOPHYLLAMINEC₃₁H₃₆N₄O₂496.6 Da
CINCHOTANNIC-ACID
CINCHOTINEC₁₉H₂₄N₂O296.4 Da
CONQUINAMINEC₁₉H₂₄N₂O₂312.4 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources