Botanical Overview
Matasano (Casimiroa edulis) is a flowering plant in the Rutaceae family. The traditional uses of this species reflect its genuine medicinal value, validated by generations of practical experience. The citrus family (Rutaceae) includes trees and shrubs with gland-dotted leaves that release aromatic oils when crushed. The flowers are typically white with four or five petals, and the fruits are often modified berries with a leathery rind. Most species produce alkaloids and limonoids with medicinal activity.

General Description
The genus is named for “an Otomi Indian, Casimiro Gómez, from the town of Cardonal in Hidalgo, Mexico, who fought and died in Mexico’s war of independence. “.
Family Context
The Rutaceae family is primarily tropical and subtropical. Notable medicinal members include:
- Kabusu — 76 documented uses
- Petitgrain — 76 documented uses
- Rue — 54 documented uses
- Orange — 47 documented uses
Geographic Distribution
Matasano has been recorded in 10 countries and territories worldwide, including Brazil, Colombia, Costa Rica, Dominican Republic, Guatemala, and others.
Traditional Uses
Matasano has been traditionally used for digestive health, skin and wound care, and pain and inflammation, among other applications.
Digestive health.
- Diarrhea
- Vermifuge
For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.
Skin and wound care.
- Ulcer
- Sore
For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.
Pain and inflammation.
- Rheumatism
For pain and inflammation, preparations are applied both topically as compresses and taken internally. A warm poultice draws blood to the area and promotes healing, while internal preparations address systemic inflammation.
Active Compounds
Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).
The identified compounds include the following categories:
- Flavonoid: antioxidant compounds that protect cells from oxidative damage
- Sterol: cholesterol-like compounds with anti-inflammatory properties
- Alkaloid: nitrogenous compounds with diverse pharmacological activities