Pawpaw

Botanical Overview

Pawpaw (Asimina triloba) belongs to the Annonaceae family. While not among the most extensively documented medicinal plants, this species has recorded uses that warrant attention from researchers and practitioners. The custard-apple family (Annonaceae) includes trees and shrubs with simple, alternate leaves and distinctive three-petaled flowers. The fruits are typically fleshy aggregates of berries. Many species produce acetogenins and isoquinoline alkaloids with potent biological activity.

General Description

It has large leaves and produces a large, yellowish-green to brown fruit.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Annonaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Pawpaw has been recorded in 10 countries and territories worldwide, including Belgium, Canada, Germany, United Kingdom, Italy, and others.

Traditional Uses

Pawpaw has been traditionally used for digestive health.

Digestive health.

  • Vermifuge

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Belgium, Canada, Germany, United Kingdom, Italy, Japan, Netherlands, Norway, United States, Unknown.

Complete Use Records

CategoryCultural Context
VermifugeUS
PediculicideUS

Complete Chemical Inventory

CompoundFormulaMW
(E)(E)-FARNESOL
(E)(E)-FARNESYL-ACETATE
(E)(E)-FARNESYL-BUTANOATE
(E)(E)-FARNESYL-HEXANOATE
(E)(E)-FARNESYL-OCTANOATE
(Z)-HEX-3-EN-1-OLC₆H₁₂O100.16 Da
2-ETHYL-HEX-AN-1-OL
3-({HEPTYLCARBONYL}OXY)BUTAN-2-ONE
3-({PENTYLCARBONYL}OXY)BUTAN-2-ONE
3-({PROPYLCARBONYL}OXY)BUTAN-2-ONE
3-ACETOXYBUTAN-2-ONE
3-HYDROXYBUTAN-2-ONEC₄H₈O₂88.11 Da
4-HEXANOLIDEC₆H₁₀O₂114.14 Da
4-OCTANOLIDEC₈H₁₄O₂142.20 Da
ALANINEC₃H₇NO₂89.09 Da
ANOLOBINEC₁₇H₁₅NO₃281.30 Da
ARGININEC₆H₁₄N₄O₂174.20 Da
ASCORBIC-ACIDC₆H₈O₆176.12 Da
ASH
ASIMICINC₃₅H₆₂O₇594.9 Da
ASIMILOBINEC₁₇H₁₇NO₂267.32 Da
ASIMINE
ASPARTIC-ACIDC₄H₇NO₄133.10 Da
BETA-CAROTENEC₄₀H₅₆536.9 Da
BUTANE-2,3-DIOL-MONOBUTANOATE-1
BUTANE-2,3-DIOL-MONOBUTANOATE-2
BUTANE-2,3-DIOL-MONOHEXANOATE-1
BUTANE-2,3-DIOL-MONOHEXANOATE-2
BUTANE-2,3-DIOL-MONOOCTANOATE-1
BUTANE-2,3-DIOL-MONOOCTANOATE-2

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources