Milkweed

Botanical Overview

Milkweed (Asclepias syriaca) is a flowering plant in the Asclepiadaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. This species belongs to the Asclepiadaceae family, a group of flowering plants.

General Description

It is native to southern Canada and much of the United States east of the Rocky Mountains, excluding the drier parts of the prairies. It is in the genus Asclepias, the milkweeds. It grows in sandy soils as well as other kinds of soils in sunny areas.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Asclepiadaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Milkweed has been recorded in 10 countries and territories worldwide, including Austria, Canada, Switzerland, France, Hungary, and others.

Traditional Uses

Milkweed has been traditionally used for digestive health, respiratory conditions, and skin and wound care, among other applications.

Digestive health.

  • Dyspepsia
  • Laxative

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Respiratory conditions.

  • Asthma
  • Expectorant
  • Pneumonia
  • Bronchitis
  • Cough

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Skin and wound care.

  • Sore
  • Ringworm
  • Wound

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Phenolic: antioxidant compounds that neutralize free radicals
  • Sterol: cholesterol-like compounds with anti-inflammatory properties
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Emetic, Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Austria, Canada, Switzerland, France, Hungary, Netherlands, Romania, Slovakia, Ukraine, United States.

Complete Use Records

CategoryCultural Context
DiureticElsewhere, Turkey, US
EmeticElsewhere, Turkey, US
AsthmaElsewhere, US
ExpectorantElsewhere, Turkey
PneumoniaElsewhere, Turkey
SoreElsewhere, US(Pamunkey)
WartUS(Appalachia), US(Rappahannock)
AlterativeTurkey
BronchitisElsewhere
CancerUS(Pamunkey)
CatharticElsewhere
CicatrizantElsewhere
CoughUS
DiaphoreticElsewhere
DyspepsiaUS
FeverElsewhere
MedicineUS(Appalachia)
MoleUS(Appalachia)
NervineTurkey
PleurisyElsewhere
PoisonTurkey
RheumatismElsewhere
RingwormUS(Rappahannock)
TumorUS
GonorrheaUS
WoundElsewhere
LaxativeUS

Complete Chemical Inventory

CompoundFormulaMW
11-OCTADECENOIC-ACIDC₁₈H₃₄O₂282.5 Da
9,12-HEXADECADIENOIC-ACIDC₁₆H₂₈O₂252.39 Da
9-HEXADECENOIC-ACIDC₁₆H₃₀O₂254.41 Da
ALPHA-AMYRINC₃₀H₅₀O426.7 Da
ASCLEPIADINC₃₁H₄₂O₁₀574.7 Da
ASH
BETA-AMYRINC₃₀H₅₀O426.7 Da
BETA-AMYRIN-ACETATEC₃₂H₅₂O₂468.8 Da
BETA-SITOSTEROLC₂₉H₅₀O414.7 Da
CAOUTCHOUCC₅H₈68.12 Da
CINNAMIC-ACIDC₉H₈O₂148.16 Da
CINNAMIC-ACID-CARDENOLIDE-ESTER
CONDURANGIN
CYMAROSEC₇H₁₄O₄162.18 Da
DESGLUCOUZARINC₂₉H₄₄O₉536.7 Da
FATC₁₆H₃₂O₂256.42 Da
GLUCOSEC₆H₁₂O₆180.16 Da
LINOLEIC-ACIDC₁₈H₃₂O₂280.4 Da
LINOLENIC-ACIDC₁₈H₃₀O₂278.4 Da
NICOTINEC₁₀H₁₄N₂162.23 Da
OLEIC-ACIDC₁₈H₃₄O₂282.5 Da
PALMITIC-ACIDC₁₆H₃₂O₂256.42 Da
POLYPHENOLS
PROTEIN
RHAMNOSEC₆H₁₂O₅164.16 Da
SYRIOBIOSIDE
SYRIOGENINC₂₃H₃₄O₅390.5 Da
TANNIN
UZARIGENINC₂₃H₃₄O₄374.5 Da
XYSMALOGENINC₂₃H₃₂O₄372.5 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources