Custard Apple

Botanical Overview

Custard Apple (Annona reticulata) is a flowering plant in the Annonaceae family. This plant has earned a place in traditional medicine through its consistent therapeutic benefits, recorded across multiple cultures. The custard-apple family (Annonaceae) includes trees and shrubs with simple, alternate leaves and distinctive three-petaled flowers. The fruits are typically fleshy aggregates of berries. Many species produce acetogenins and isoquinoline alkaloids with potent biological activity.

General Description

It is best known for its fruit, called custard apple, a common name shared with fruits of several other species in the same genus: A. cherimola and A. squamosa. Other English common names include ox heart and bullock’s heart. The fruit is sweet and useful in preparation of desserts, but is generally less popular for eating than that of A. cherimola.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Annonaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Custard Apple has been recorded in 10 countries and territories worldwide, including Brazil, Colombia, Costa Rica, Dominican Republic, Guatemala, and others.

Traditional Uses

Custard Apple has been traditionally used for digestive health, respiratory conditions, and skin and wound care, among other applications.

Digestive health.

  • Diarrhea
  • Dysentery
  • Vermifuge

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Respiratory conditions.

  • Pectoral

Respiratory conditions are addressed through steam inhalation of the herb’s vapors or internal use as a warm tea. The hot infusion acts as an expectorant, helping to loosen phlegm and clear congestion. Some traditions combine it with honey for coughs.

Skin and wound care.

  • Boil

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Active Compounds

Phytochemical research has identified 30 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Coumarin: aromatic compounds with anticoagulant and anti-inflammatory effects
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.
⚠ Caution
Traditional records: This plant has documented uses including Poison. Self-medication with herbs carries risks including allergic reactions, drug interactions, and toxicity. Only use under the supervision of a qualified healthcare professional.

Distribution and Conservation

Reported distribution: Brazil, Colombia, Costa Rica, Dominican Republic, Guatemala, India, Mexico, Nicaragua, Reunion, El Salvador.

Complete Use Records

CategoryCultural Context
DiarrheaDominican Republic, Java, Latin America
DysenteryFrench, Haiti, Johore
TonicElsewhere, India, Malaya
AstringentElsewhere, Malaysia
EpilepsyElsewhere, Malaya
VermifugeElsewhere, German
ConvulsionMalaya
DiureticHaiti
FeverMalaya
HepatomegalyJava
InflammationElsewhere
InsecticideElsewhere
PectoralHaiti
PediculicideJava
SpasmHaiti
Ache(Tooth)Malaya
BoilMalaya
PoisonUS
Tumor

Complete Chemical Inventory

CompoundFormulaMW
1,2-DISEHYDRONORCOCLAURINEC₁₆H₁₅NO₃269.29 Da
14-HYDROXY-25-DESOXYROLLINICINC₃₇H₆₆O₈638.9 Da
ANONAINEC₁₇H₁₅NO₂265.31 Da
ASCORBIC-ACIDC₆H₈O₆176.12 Da
ASH
BETA-CAROTENEC₄₀H₅₆536.9 Da
CALCIUMCa40.08 Da
CARBOHYDRATES
COCLAURINEC₁₇H₁₉NO₃285.34 Da
COUMARINSC₁₉H₁₆O₄308.3 Da
DOPAMINEC₈H₁₁NO₂153.18 Da
FATC₁₆H₃₂O₂256.42 Da
FIBER
HCNCHN27.025 Da
HEXADECANOIC-ACIDC₁₆H₂₉O₂-₃253.40 Da
IRONFe55.84 Da
KILOCALORIES
LEUCOANTHOCYANINS
LINOLEIC-ACIDC₁₈H₃₂O₂280.4 Da
LIRODENINEC₂₆H₁₈N₂O₂P₂452.4 Da
LYSINEC₆H₁₄N₂O₂146.19 Da
MAGNESIUMMg24.305 Da
METHIONINEC₅H₁₁NO₂S149.21 Da
MICHELALBINEC₁₇H₁₅NO₃281.30 Da
MURICININEC₁₈H₁₉NO₄313.3 Da
MYRISTIC-ACIDC₁₄H₂₈O₂228.37 Da
NIACINC₆H₅NO₂123.11 Da
NICOTINIC-ACIDC₆H₅NO₂123.11 Da
NORCOCLAURINEC₁₆H₁₇NO₃271.31 Da
NORCOCLAURINE-CARBOXYLIC-ACID

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources