Creat

Botanical Overview

Creat (Andrographis paniculata) is a flowering plant in the Acanthaceae family. Traditional medicine systems have documented several valuable applications for this species, supported by its observed therapeutic effects. The acanthus family (Acanthaceae) includes herbs and shrubs with opposite leaves and showy, two-lipped flowers with prominent bracts. The fruits are explosive capsules that eject seeds when mature. Many species contain alkaloids and have traditional medicinal uses.

General Description

It is widely cultivated in Southern and Southeastern Asia, where it has been believed to be a treatment for bacterial infections and some diseases. Mostly the leaves and roots have been used for such purposes; the whole plant is also used, in some cases.

ⓘ Information
Description adapted from Wikipedia (CC BY-SA 4.0).

Family Context

The Acanthaceae family is widely distributed. Notable medicinal members include:

Geographic Distribution

Creat has been recorded in 10 countries and territories worldwide, including Australia, China, Indonesia, India, Jamaica, and others.

Traditional Uses

Creat has been traditionally used for digestive health, skin and wound care, and pain and inflammation, among other applications.

Digestive health.

  • Dysentery
  • Diarrhea
  • Stomachic
  • Ache(Stomach)
  • Colic

For digestive complaints, the herb is typically prepared as a tea or decoction taken before meals. The bitter compounds stimulate digestive secretions and improve nutrient absorption. Some traditions use the powdered root or leaves in small doses as a stomachic tonic.

Skin and wound care.

  • Abscess

For skin conditions, the fresh or dried plant is applied topically as a poultice, wash, or compress. A strong decoction can be used to clean wounds and sores. The antimicrobial properties help prevent infection while promoting tissue repair.

Pain and inflammation.

  • Anodyne
  • Swelling

For pain and inflammation, preparations are applied both topically as compresses and taken internally. A warm poultice draws blood to the area and promotes healing, while internal preparations address systemic inflammation.

Active Compounds

Phytochemical research has identified 11 compounds in this species, including a diverse array of phytochemical classes (see the Complete Chemical Inventory below for the full list).

The identified compounds include the following categories:

  • Flavonoid: antioxidant compounds that protect cells from oxidative damage
  • Alkaloid: nitrogenous compounds with diverse pharmacological activities
ⓘ Information
Information on this page is compiled from Dr. Duke’s Phytochemical and Ethnobotanical Databases (USDA ARS), a public domain resource. Consult a healthcare professional before using any herbal preparation.

Distribution and Conservation

Reported distribution: Australia, China, Indonesia, India, Jamaica, Malaysia, Philippines, Singapore, Thailand, Taiwan.

Complete Use Records

CategoryCultural Context
DysenteryChina, India, Malaya
AlterativeArabic, Elsewhere
AnodyneChina, Malaysia
Bite(Snake)China, Java
DiarrheaIndia, India(Santal)
FeverChina, Java
StomachicElsewhere, Malaysia
AbscessChina
Ache(Stomach)India(Santal)
AnthelminthicElsewhere
AstringentIran
Bite(Dog)India(Santal)
BugbiteJava
CholeraIndia(Santal)
ColicIndia(Santal)
TuberculosisIndia(Santal)
DetoxicantChina
DiabetesJava
EnteritisChina
FebrifugeElsewhere
MalariaMalaya
PhthisisIndia(Santal)
PyelonephritisChina
SplenitisIndia(Santal)
SwellingChina
TonicIndia
TonsillitisChina
AlexipharmicItalian
AntisepticChina
BactericideIndia

Complete Chemical Inventory

CompoundFormulaMW
14-DEOXY-11-DEHYDROANDROGRAPHOLIDE
14-DEOXY-11-OXOANDROGRAPHOLIDEC₂₀H₂₈O₅348.4 Da
5-HYDROXY-7,8,2',3'-TETRAMETHOXYFLAVONEC₁₉H₁₈O₇358.3 Da
5-HYDROXY-7,8,2'-TRIMETHOXYFLAVONEC₁₈H₁₆O₆328.3 Da
ANDROGRAPHINE
ANDROGRAPHOLIDEC₂₀H₃₀O₅350.4 Da
NEOANDROGRAPHOLIDEC₂₆H₄₀O₈480.6 Da
PANICOLINE
PANICULIDE-AC₁₅H₂₀O₄264.32 Da
PANICULIDE-BC₁₅H₂₀O₅280.32 Da
PANICULIDE-CC₁₅H₁₈O₅278.30 Da

Data from PubChem (NIH/NLM, public domain).


References & Further Reading

External Research Links

Data Sources