Before we begin: Fifth disease (erythema infectiosum) is a mild infection caused by parvovirus.
This tutorial walks you through everything you need to know about fifth disease. We explain it in plain language, step by step, so whether you are a student, a patient, or simply curious, you will come away with a solid understanding.
We cover what it is, why it matters, how it is diagnosed, and what you can do about it. Key facts are called out along the way.
What is fifth disease? Fifth disease, also called erythema infectiosum, is a viral infection caused by parvovirus B19. This virus only infects people; it’s not the same type of parvovirus that dogs and cats can get.
Fifth disease mostly affects children. It often causes a bright red rash on their cheeks (sometimes called a “slapped cheek” rash).
In the United States, parvovirus B19 infections are more common in late winter, spring, and early summer. There are usually minor outbreaks of fifth disease about every 3 to 4 years.
What causes fifth disease? Parvovirus B19, which causes fifth disease, can spread from person to person:
Through respiratory droplets, such as saliva (spit), sputum, or nasal mucus. The droplets can spread when:
Someone who has the virus coughs and sneezes
You touch an item that has the virus on it
Through blood or blood products
From a pregnant parent to the baby during pregnancy
You are most contagious early in your infection, when you usually only have a fever or cold-like symptoms. You are not likely to be contagious after you get later symptoms such as a rash and joint pain.
What are the symptoms of fifth disease? About 2 out of 10 people who get a B19 parvovirus infection will have no symptoms.
But most people will get the symptoms of fifth disease, which are usually mild and can include:
Fever
Headache
Cough
Sore throat
Rashes
Joint pain
The “slapped cheek” rash is more common in children. They usually get the rash a few days after they first have other symptoms. The rash can then spread to the arms, legs, chest, back, and buttocks.
Adults who get fifth disease might also have joint pain and swelling (called polyarthropathy syndrome).
Sometimes the infection can cause serious health complications affecting the nerves, joints, or blood system. This is more likely to happen if you are pregnant, have a blood disorder such as anemia, or a weakened immune system.
Because of these risks to you and some possible risks to your baby, contact your health care provider if you are pregnant and:
You show signs of fifth disease (or a “slapped cheek” rash)
You may have been exposed to someone who has the infection
How is fifth disease diagnosed? There is no routine lab test to diagnose fifth disease. Providers can often diagnose fifth disease just by seeing the “slapped cheek” rash and rashes on the body.
There is testing to show whether or not you have protection (immunity) against the B19 parvovirus or if you have had a recent infection. This test is usually not needed, but your provider may order the test if you are pregnant or at higher risk for complications of the disease.
What are the treatments for fifth disease? There is no specific treatment for fifth disease. It is usually mild and goes away on its own.
To feel better, get plenty of rest. Taking acetaminophen can help with the fever and pain. Do not give aspirin to children, because it may cause Reye syndrome. This is a rare, serious illness that can affect the brain and liver.
Can fifth disease be prevented? There is no vaccine to prevent fifth disease. But you can help protect yourself and others by:
Washing your hands often with soap and water
Covering your mouth and nose when you cough or sneeze
Avoiding touching your eyes, nose, and mouth with unwashed hands
Avoiding close contact with people who are sick
Staying home when you are sick
Most people become immune to the virus after having it once.
Centers for Disease Control and Prevention
Also known as: Erythema infectiosum, Parvovirus B19 infection.
Related topics: Erythema Infectiosum, Parvovirus B19.
Categories: Children and Teenagers, Infections, Skin, Hair and Nails.
Source: National Institutes of Health — National Institute of Allergy and Infectious Diseases.
Key Takeaways
Understanding fifth disease is an important part of taking charge of your health. Here is what to remember:
- Know the signs — Recognizing early symptoms can lead to earlier diagnosis and better outcomes.
- Talk to your provider — If you have concerns or a family history of this condition, bring it up at your next checkup.
- Stay informed — Medical knowledge evolves. Keep learning and asking questions.
- You are not alone — Many people deal with this condition. Support groups and educational resources can help.