Zolpidem Tartrate (7 brand names, 5 dosage forms, 2 routes)
Available dosage forms: TABLET, TABLET, EXTENDED RELEASE, CAPSULE, TABLET, ORALLY DISINTEGRATING, SPRAY, METERED.
Routes of administration: ORAL, SUBLINGUAL.
Brand Names
- AMBIEN
- AMBIEN CR
- EDLUAR
- INTERMEZZO
- TOVALT ODT
- ZOLPIDEM TARTRATE
- ZOLPIMIST
Boxed Warning
Complex sleep behaviors including sleep-walking, sleep-driving, and engaging in other activities while not fully awake may occur following use of zolpidem tartrate tablets. Some of these events may result in serious injuries, including death. Discontinue zolpidem tartrate tablets immediately if a patient experiences a complex sleep behavior [see Contraindications ( 4) and Warnings and Precautions ( 5.1)] .
Mechanism of Action
Zolpidem is a GABA A receptor positive modulator presumed to exert its therapeutic effects in the short-term treatment of insomnia through binding to the benzodiazepine site of α1 subunit containing GABA A receptors, increasing the frequency of chloride channel opening resulting in the inhibition of neuronal excitation.