Vemurafenib (1 brand name, 1 dosage form, 1 route)
Available dosage forms: TABLET.
Routes of administration: ORAL.
Brand Names
- ZELBORAF
Contraindications
None.
Adverse Reactions
The following adverse reactions are discussed in greater detail in other sections of the label: New Primary Malignancies [see Warnings and Precautions (5.1)] Hypersensitivity Reactions [see Warnings and Precautions (5.3)] Dermatologic Reactions [see Warnings and Precautions (5.4)] QT Prolongation [see Warnings and Precautions (5.5)] Hepatotoxicity [see Warnings and Precautions (5.6)] Photosensitivity [see Warnings and Precautions (5.7)] Ophthalmologic Reactions [see Warnings and Precautions (5.8)] Radiation Sensitization and Radiation Recall [see Warnings and Precautions (5.10)] Renal Failure [see Warnings and Precautions (5.11)] Dupuytren’s Contracture and Plantar Fascial Fibromatosis [see Warnings and Precautions (5.12)]
Mechanism of Action
Vemurafenib is a low molecular weight, orally available inhibitor of some mutated forms of BRAF serine- threonine kinase, including BRAF V600E. Vemurafenib also inhibits other kinases in vitro such as CRAF, ARAF, wild-type BRAF, SRMS, ACK1, MAP4K5, and FGR at similar concentrations. Some mutations in the BRAF gene including V600E result in constitutively activated BRAF proteins, which can cause cell proliferation in the absence of growth factors that would normally be required for proliferation. Vemurafenib has anti-tumor effects in cellular and animal models of melanomas with mutated BRAF V600E.
Overdosage
There is no information on overdosage of ZELBORAF.