Treprostinil (4 brand names, 4 dosage forms, 3 routes)
Available dosage forms: INJECTABLE, SOLUTION, POWDER, TABLET, EXTENDED RELEASE.
Routes of administration: INTRAVENOUS, SUBCUTANEOUS, INHALATION, ORAL.
Brand Names
- REMODULIN
- TREPROSTINIL
- TYVASO
- TYVASO DPI
Contraindications
None.
Adverse Reactions
The following potential adverse reactions are described in Warnings and Precautions (5): -Decrease in systemic blood pressure [see Warnings and Precautions (5.1)]. -Bleeding [see Warnings and Precautions (5.2)].
Mechanism of Action
Treprostinil is a prostacyclin analogue. The major pharmacologic actions of treprostinil are direct vasodilation of pulmonary and systemic arterial vascular beds and inhibition of platelet aggregation.
Overdosage
In general, symptoms of overdose with Tyvaso include flushing, headache, hypotension, nausea, vomiting, and diarrhea. Provide general supportive care until the symptoms of overdose have resolved.