Tetracaine Hydrochloride (2 brand names, 2 dosage forms, 2 routes)
Available dosage forms: SOLUTION, SPRAY, METERED.
Routes of administration: OPHTHALMIC, NASAL.
Brand Names
- KOVANAZE
- TETRACAINE HYDROCHLORIDE
Indications and Usage
Tetracaine Hydrochloride Ophthalmic Solution, USP 0.5% is indicated for procedures requiring a rapid and short-acting topical ophthalmic anesthetic.
Dosage and Administration
One drop topically in the eye(s) as needed.
Contraindications
Tetracaine Hydrochloride Ophthalmic Solution, USP 0.5% should not be used in patients with a history of hypersensitivity to any component of this preparation.
Adverse Reactions
The following serious ocular adverse reactions are described elsewhere in the labeling: Corneal Injury with Intracameral Use [see Warnings and Precautions (5.1)] Corneal Toxicity [see Warnings and Precautions (5.2)] Corneal Injury Due to Insensitivity [see Warnings and Precautions (5.3)] The following adverse reactions have been identified following use of Tetracaine Hydrochloride Ophthalmic Solution, USP 0.5%. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Ocular Adverse Reactions Transient stinging, burning, and conjunctival redness, eye irritation, eye pain, ocular discomfort.
Mechanism of Action
Tetracaine blocks sodium ion channels required for the initiation and conduction of neuronal impulses thereby affecting local anesthesia.
Overdosage
Prolonged use of a topical ocular anesthetic including Tetracaine Hydrochloride Ophthalmic Solution, USP 0.5% may produce permanent corneal opacification and ulceration with accompanying visual loss.