Terconazole (3 brand names, 2 dosage forms, 1 route)
Available dosage forms: SUPPOSITORY, CREAM.
Routes of administration: VAGINAL.
Brand Names
- TERAZOL 3
- TERAZOL 7
- TERCONAZOLE
Indications and Usage
Terconazole Vaginal Suppositories, 80 mg is indicated for the local treatment of vulvovaginal candidiasis (moniliasis). As this product is effective only for vulvovaginitis caused by the genus Candida, the diagnosis should be confirmed by KOH smears and/or cultures.
Dosage and Administration
One Terconazole Vaginal Suppository (80 mg terconazole) should be administered intravaginally once daily at bedtime for three consecutive days. Before prescribing another course of therapy, the diagnosis should be reconfirmed by smears and/or cultures and other pathogens commonly associated with vulvovaginitis ruled out. The therapeutic effect of terconazole vaginal suppositories is not affected by menstruation.
Contraindications
Patients known to be hypersensitive to terconazole or to any of the components of the suppositories.
Drug Interactions
The therapeutic effect of this product is not affected by oral contraceptive usage.
Mechanism of Action
Terconazole, an azole antifungal agent, inhibits fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylase enzyme. This enzyme functions to convert lanosterol to ergosterol. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell wall and may be responsible for the antifungal activity of terconazole. Mammalian cell demethylation is less sensitive to terconazole inhibition.
Overdosage
In the rat, the oral LD 50values were found to be 1741 and 849 mg/kg for the male and female, respectively. The oral LD 50values for the male and female dog were ≅1280 and ≥640 mg/kg, respectively. In the event of oral ingestion of suppository or cream, supportive and symptomatic measures should be carried out. If the cream is accidentally applied to the eyes, wash with clean water or saline and seek medical attention if symptoms persist.