Soybean Oil (18 brand names, 2 dosage forms, 2 routes)
Available dosage forms: EMULSION, INJECTABLE.
Routes of administration: INTRAVENOUS, INJECTION.
Brand Names
- CLINOLIPID 20%
- INTRALIPID 10%
- INTRALIPID 20%
- INTRALIPID 30%
- KABIVEN IN PLASTIC CONTAINER
- LIPOSYN II 10%
- LIPOSYN II 20%
- LIPOSYN III 10%
- LIPOSYN III 20%
- LIPOSYN III 30%
- NUTRILIPID 10%
- NUTRILIPID 20%
- PERIKABIVEN IN PLASTIC CONTAINER
- SMOFLIPID 20%
- SOYACAL 10%
- SOYACAL 20%
- TRAVAMULSION 10%
- TRAVAMULSION 20%
Indications and Usage
CLINOLIPID is indicated in adults and pediatric patients, including term and preterm neonates, as a source of calories and essential fatty acids for parenteral nutrition (PN) when oral or enteral nutrition is not possible, insufficient, or contraindicated.
Contraindications
The use of CLINOLIPID is contraindicated in patients with the following: • Known hypersensitivity to egg, soybean, peanut or to any of the active or inactive ingredients in CLINOLIPID [see Warnings and Precautions (5.3) ] . • Severe disorders of lipid metabolism characterized by hypertriglyceridemia (serum triglyceride >1,000 mg/dL) [see Warnings and Precautions (5.7) ] .
Adverse Reactions
The following clinically significant adverse reactions are described elsewhere in the labeling: •Clinical Decompensation with Rapid Infusion of Intravenous Lipid Emulsion in Neonates and Infants [see Warnings and Precautions (5.1)] •Parenteral Nutrition-Associated Liver Disease and Other Hepatobiliary Disorders [see Warnings and Precautions (5.2)] •Hypersensitivity reactions [see Warnings and Precautions (5.3)] •Infections [see Warnings and Precautions (5.4)] •Fat overload syndrome [see Warnings and Precautions (5.5)] •Refeeding syndrome [see Warnings and Precautions (5.6)] •Hypertriglyceridemia [see Warnings and Precautions (5.7)] •Aluminum toxicity [see Warnings and Precautions (5.8)] •Essential Fatty Acid Deficiency [see Warnings and Precautions (5.9)]
Drug Interactions
No drug interaction studies have been performed with CLINOLIPID. Olive and soybean oils have a natural content of Vitamin K1 that may counteract the anticoagulant activity of coumadin derivatives, including warfarin.
Mechanism of Action
Fatty acids serve as an important substrate for energy production. The most common mechanism of action for energy production derived from fatty acid metabolism is beta oxidation. Fatty acids are important for membrane structure and function, precursors for bioactive molecules (such as prostaglandins), and as regulators of gene expression.
Overdosage
In the event of overdose, serious adverse reactions may result [see Warnings and Precautions (5.1, 5.5 )]. Stop the infusion to allow lipids to clear from serum. The effects are usually reversible after the lipid infusion is stopped. If medically appropriate, further intervention may be indicated. The lipid administered and fatty acids produced are not dialyzable.