Norepinephrine Bitartrate (5 brand names, 2 dosage forms, 2 routes)
Available dosage forms: INJECTABLE, SOLUTION.
Routes of administration: INJECTION, INTRAVENOUS.
Brand Names
- LEVOPHED
- NOREPINEPHRINE BITARTRATE
- NOREPINEPHRINE BITARTRATE IN 0.9% SODIUM CHLORIDE
- NOREPINEPHRINE BITARTRATE IN 5% DEXTROSE
- RAVOCAINE AND NOVOCAIN W/ LEVOPHED
Indications and Usage
Norepinephrine bitartrate injection is indicated to raise blood pressure in adult patients with severe, acute hypotension.
Contraindications
None.
Adverse Reactions
The following adverse reactions are described in greater detail in other sections: •Tissue Ischemia [see Warnings and Precautions (5.1)] •Hypotension [see Warnings and Precautions (5.2)] •Cardiac Arrhythmias [see Warnings and Precautions (5.3)] The most common adverse reactions are hypertension and bradycardia. The following adverse reactions can occur: Nervous system disorders: Anxiety, headache Respiratory disorders: Respiratory difficulty, pulmonary edema
Mechanism of Action
Norepinephrine is a peripheral vasoconstrictor (alpha-adrenergic action) and an inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action).
Overdosage
Overdosage with norepinephrine may result in headache, severe hypertension, reflex bradycardia, marked increase in peripheral resistance, and decreased cardiac output. In case of overdosage, discontinue norepinephrine until the condition of the patient stabilizes.