Nitazoxanide (2 brand names, 2 dosage forms, 1 route)
Available dosage forms: FOR SUSPENSION, TABLET.
Routes of administration: ORAL.
Brand Names
- ALINIA
- NITAZOXANIDE
Indications and Usage
Diarrhea caused by Giardia lamblia or Cryptosporidium parvum: Nitazoxanide tablets (patients 12 years and older) are indicated for the treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum. Limitations of Use Nitazoxanide tablets have not been shown to be effective for the treatment of diarrhea caused by Cryptosporidium parvum in HIV-infected or immunodeficient patients [see Clinical Studies (14.2)].
Mechanism of Action
Nitazoxanide is an antiprotozoal [ see Microbiology (12.4) ].
Overdosage
Limited information on nitazoxanide overdosage is available. In the event of overdose, gastric lavage may be appropriate soon after oral administration. Patients should be observed and given symptomatic and supportive treatment. There is no specific antidote for overdose with nitazoxanide. Because tizoxanide is highly protein bound (>99.9%), dialysis is unlikely to significantly reduce plasma concentrations of the drug.