Nepafenac (2 brand names, 1 dosage form, 1 route)
Available dosage forms: SUSPENSION/DROPS.
Routes of administration: OPHTHALMIC.
Brand Names
- ILEVRO
- NEVANAC
Indications and Usage
ILEVRO ®0.3% is indicated for the treatment of pain and inflammation associated with cataract surgery.
Contraindications
ILEVRO ®0.3% is contraindicated in patients with previously demonstrated hypersensitivity to any of the ingredients in the formula or to other nonsteroidal anti-inflammatory drugs (NSAIDs).
Adverse Reactions
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to the rates in the clinical studies of another drug and may not reflect the rates observed in practice.
Mechanism of Action
After topical ocular dosing, nepafenac penetrates the cornea and is converted by ocular tissue hydrolases to amfenac, a NSAID. Nepafenac and amfenac are thought to inhibit the action of prostaglandin H synthase (cyclooxygenase), an enzyme required for prostaglandin production.