Nandrolone Decanoate (2 brand names, 1 dosage form, 1 route)
Available dosage forms: INJECTABLE.
Routes of administration: INJECTION.
Brand Names
- DECA-DURABOLIN
- NANDROLONE DECANOATE
Indications and Usage
Nandrolone decanoate is indicated for the management of the anemia of renal insufficiency and has been shown to increase hemoglobin and red cell mass. Surgically induced anephric patients have been reported to be less responsive.
Dosage and Administration
Nandrolone decanoate injection is intended for deep intramuscular injection only, into the gluteal muscle preferably.Dosage should be based on therapeutic response and consideration of the benefit to risk ratio. Duration of therapy will depend on the response of the condition and the appearance of adverse reactions. If possible, therapy should be intermittent.Nandrolone decanoate should be regarded as adjunctive therapy and adequate quantities of nutrients should be consumed in order to obtain maximal therapeutic effects. For example, when it is used in the treatment of refractory anemia, adequate iron intake is required for a maximal response.Anemia of Renal DiseaseA dose of 50 to 100 mg per week is recommended for women and 100 to 200 mg per week for men. Drug therapy should be discontinued if no hematologic improvement is seen within the first six months. For children from 2 to 13 years of age, the average dose is 25 to 50 mg every 3 to 4 weeks.Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit.
Contraindications
Male patients with carcinoma of the breast or with known or suspected carcinoma of the prostate.Carcinoma of the breast in females with hypercalcemia: androgenic anabolic steroids may stimulate osteolytic resorption of bones.Pregnancy, because of masculinization of the fetus.Nephrosis or the nephrotic phase of nephritis.
Adverse Reactions
Hepatic:Hepatocellular neoplasms and peliosis hepatis have been reported in association with long-term androgenic anabolic steroid therapy (see WARNINGS section).Genitourinary System:In men. a. Prepubertal: Phallic enlargement and increased frequency of erections. b. Postpubertal: Inhibition of testicular function, testicular atrophy and oligospermia, impotence, chronic priapism, epididymitis and bladder irritability.In women: Clitoral enlargement, menstrual irregularities.In both sexes: Increased or decreased libido.CNS:Habituation, excitation, insomnia, depression.Gastrointestinal:Nausea, vomiting, diarrhea.Hematologic:Bleeding in patients on concomitant anticoagulant therapy (see PRECAUTIONS, Drug Interactions).Breast:Gynecomastia.Larynx:Deepening of the voice in women.Hair:Hirsutism and male pattern of baldness in women.Skin:Acne (especially in women and prepubertal boys.)Skeletal:Premature closure of epiphyses in children (see PRECAUTIONS, Pediatric use).Fluid and Electrolytes:Edema, retention of serum electrolytes (sodium, chloride, potassium, phosphate, calcium).Metabolic/Endocrine:Decreased glucose tolerance (see PRECAUTIONS, General), increased serum levels of low-density lipoprotein and decreased levels of high-density lipoprotein (see PRECAUTIONS, Laboratory tests), increased creatine and creatinine excretion, increased serum levels of creatinine phosphokinase (CPK). Some virilizing changes in women are irreversible even after prompt discontinuance of therapy and are not prevented by concomitant use of estrogens (see PRECAUTIONS).
Drug Interactions
Anticoagulants. Anabolic steroids may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may have to be decreased in order to maintain the prothrombin time at the desired therapeutic level. Patients receiving oral anticoagulant therapy require close monitoring, especially when anabolic steroids are started or stopped.
Overdosage
There have been no reports of acute overdosage with the anabolics.