Nalmefene Hydrochloride (4 brand names, 2 dosage forms, 3 routes)
Available dosage forms: SOLUTION, SPRAY.
Routes of administration: INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS, INTRAMUSCULAR, SUBCUTANEOUS, NASAL.
Brand Names
- NALMEFENE HYDROCHLORIDE
- OPVEE
- REVEX
- ZURNAI (AUTOINJECTOR)
Indications and Usage
ZURNAI is indicated for the emergency treatment of known or suspected opioid overdose induced by natural or synthetic opioids in adults and pediatric patients aged 12 years and older, as manifested by respiratory and/or central nervous system depression. ZURNAI is intended for immediate administration as emergency therapy in settings where opioids may be present. ZURNAI is not a substitute for emergency medical care.
Contraindications
ZURNAI is contraindicated in patients known to be hypersensitive to nalmefene hydrochloride or to any other ingredients in the product.
Adverse Reactions
The following serious adverse reactions are described elsewhere in the labeling: Recurrent Respiratory and Central Nervous System Depression [see Warnings and Precautions (5.1)] Precipitation of Severe Opioid Withdrawal [see Warnings and Precautions (5.3)]
Mechanism of Action
ZURNAI is an antagonist at opioid receptors.