Mechlorethamine Hydrochloride (2 brand names, 2 dosage forms, 2 routes)
Available dosage forms: GEL, INJECTABLE.
Routes of administration: TOPICAL, INJECTION.
Brand Names
- MUSTARGEN
- VALCHLOR
Indications and Usage
VALCHLOR is indicated for the topical treatment of Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma in patients who have received prior skin-directed therapy.
Contraindications
The use of VALCHLOR is contraindicated in patients with known severe hypersensitivity to mechlorethamine. Hypersensitivity reactions, including anaphylaxis, have occurred with topical formulations of mechlorethamine.
Adverse Reactions
The following clinically significant adverse reactions are discussed in greater detail in other sections of the prescribing information: Mucosal or eye injury [see Warnings and Precautions (5.1)] Secondary exposure to VALCHLOR [see Warnings and Precautions (5.2)] Dermatitis [see Warnings and Precautions (5.3)] Non-melanoma skin cancer [see Warnings and Precautions (5.4)]
Drug Interactions
No drug interaction studies have been performed with VALCHLOR. Systemic exposure has not been observed with topical administration of VALCHLOR; therefore, systemic drug interactions are not likely.
Mechanism of Action
Mechlorethamine, also known as nitrogen mustard, is an alkylating agent which inhibits rapidly proliferating cells.