Mannitol (27 brand names, 3 dosage forms, 3 routes)
Available dosage forms: INJECTABLE, SOLUTION, POWDER.
Routes of administration: INJECTION, IRRIGATION, INHALATION.
Brand Names
- ARIDOL
- ARIDOL KIT
- BRONCHITOL
- MANNITOL 10%
- MANNITOL 10% IN PLASTIC CONTAINER
- MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
- MANNITOL 15%
- MANNITOL 15% IN PLASTIC CONTAINER
- MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%
- MANNITOL 20%
- MANNITOL 20% IN PLASTIC CONTAINER
- MANNITOL 25%
- MANNITOL 5%
- MANNITOL 5% IN PLASTIC CONTAINER
- MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%
- OSMITROL 10% IN WATER
- OSMITROL 10% IN WATER IN PLASTIC CONTAINER
- OSMITROL 15% IN WATER
- OSMITROL 15% IN WATER IN PLASTIC CONTAINER
- OSMITROL 20% IN WATER …and 7 more
Indications and Usage
Sorbitol-Mannitol Irrigation is indicated for use as a urologic irrigating fluid during transurethral prostatic resection and other transurethral surgical procedures.
Dosage and Administration
Sorbitol-Mannitol Irrigation should be administered only by transurethral instillation with appropriate urologic instrumentation. A disposable administration set should be used. The total volume of solution used for irrigation is solely at the discretion of the surgeon. Height of container(s) above the operating table in excess of 60 cm (approx. 2 ft) has been reported to increase intravascular absorption of the irrigating fluid. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever container and solution permit. (See PRECAUTIONS .)
Contraindications
NOT FOR INJECTION BY USUAL PARENTERAL ROUTES. Do not use in patients with anuria.
Adverse Reactions
Adverse reactions may result from intravascular absorption of sorbitol and mannitol. The literature reports occasional adverse reactions from intravenous sorbitol-mannitol infusions. Consequences of absorption of urologic irrigating solutions include fluid and electrolyte disturbances such as acidosis, electrolyte loss, marked diuresis, urinary retention, edema, dryness of mouth, thirst and dehydration; cardiovascular disorders such as hypotension, tachycardia, angina-like pains; pulmonary disorders such as pulmonary congestion; and other general reactions such as blurred vision, convulsions, nausea, vomiting, diarrhea, rhinitis, chills, vertigo, backache and urticaria. Allergic reactions from sorbitol-mannitol have also been reported. Should any adverse reaction occur, discontinue the irrigant, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
Overdosage
In the event of dehydration, fluid or solute overload, discontinue the irrigation, evaluate the patient and institute corrective measures as indicated. (See WARNINGS , PRECAUTIONS and ADVERSE REACTIONS .)