Loxapine (1 brand name, 1 dosage form, 1 route)
Available dosage forms: POWDER.
Routes of administration: INHALATION.
Brand Names
- ADASUVE
Indications and Usage
ADASUVE is indicated for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults [see Clinical Studies (14)] .
Contraindications
ADASUVE is contraindicated in patients with the following: Current diagnosis or history of asthma, COPD, or other lung disease associated with bronchospasm [see Warnings and Precautions (5.1)] Acute respiratory symptoms or signs (e.g., wheezing) [see Warnings and Precautions (5.1)] Current use of medications to treat airways disease, such as asthma or COPD [see Warnings and Precautions (5.1)] History of bronchospasm following ADASUVE treatment [see Warnings and Precautions (5.1)] Known hypersensitivity to loxapine or amoxapine. Serious skin reactions have occurred with oral loxapine and amoxapine.
Adverse Reactions
The following adverse reactions are discussed in more detail in other sections of the labeling: Hypersensitivity (serious skin reactions) [see Contraindications (4)] Bronchospasm [see Warnings and Precautions (5.1)] Increased Mortality in Elderly Patients with Dementia-Related Psychosis [see Warnings and Precautions (5.3)] Neuroleptic Malignant Syndrome [see Warnings and Precautions (5.4)] Hypotension and syncope [see Warnings and Precautions (5.5)] Falls [see Warnings and Precautions (5.6)] Seizure [see Warnings and Precautions (5.7)] Potential for Cognitive and Motor Impairment [see Warnings and Precautions (5.8)] Cerebrovascular Reactions, Including Stroke, in Elderly Patients with Dementia-Related Psychosis [see Warnings and Precautions (5.9)] Anticholinergic Reactions Including Exacerbation of Glaucoma and Urinary Retention [see Warnings and Precautions (5.10)]
Mechanism of Action
The mechanism of action of loxapine in the treatment of agitation associated with schizophrenia and bipolar I disorder is unclear. However, its efficacy could be mediated through a combination of antagonism of central serotonin and dopamine receptors.