Lotilaner (1 brand name, 1 dosage form, 1 route)
Available dosage forms: SOLUTION/DROPS.
Routes of administration: OPHTHALMIC.
Brand Names
- XDEMVY
Indications and Usage
Credelio Quattro is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater. Credelio Quattro is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. Credelio Quattro-CA1 is indicated for the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.
Dosage and Administration
Credelio Quattro/Credelio Quattro-CA1 is given orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Credelio Quattro/Credelio Quattro-CA1 must be administered with food (see Clinical Pharmacology ). Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If vomiting occurs within an hour after administration, readminister a new dose of Credelio Quattro/Credelio Quattro-CA1. Credelio Quattro: Credelio Quattro is given once a month. If a dose is missed, give Credelio Quattro immediately and resume a monthly dosing schedule. Dosing Schedule: As pamoate salt Body Weight (lbs) Tablets to Administer Lotilanerper Tablet (mg) Moxidectinper Tablet (mg) Praziquantelper Tablet (mg) Pyrantelper Tablet (mg) 3.3 – 6 1 56.25 0.056 14.25 14.25 6.1 – 12 1 112.5 0.113 28.5 28.5 12.1 – 25 1 225 0.225 57 57 25.1 – 50 1 450 0.45 114 114 50.1 – 100 1 900 0.9 228 228 > 100 Administer the appropriate combination of tablets Heartworm Prevention Credelio Quattro should be administered year-round at monthly intervals or at least within 1 month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure. If a dose is missed, give Credelio Quattro immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, Credelio Quattro should be given within 1 month of the last dose of the former medication. Intestinal Nematode and Cestode Treatment and Control Credelio Quattro should be administered as a single dose for the treatment of roundworm, hookworm, and tapeworm infections. Monthly use of Credelio Quattro will control any subsequent infections. Dogs may be exposed to and can become infected with gastrointestinal worms throughout the year, regardless of season or climate. Clients should be advised o
Contraindications
There are no known contraindications for the use of Credelio Quattro/Credelio Quattro-CA1.
Adverse Reactions
In a field safety and effectiveness study, Credelio Quattro was administered to dogs for the prevention of heartworm disease. The study included a total of 372 dogs treated once monthly for up to 11 treatments (191 treated with Credelio Quattro and 181 treated with an active control). Over the 330-day study period, all observations of potential adverse reactions were recorded. Adverse reactions seen during the field study are summarized in the table below. Dogs with Adverse Reactions in the Field Study Four dogs administered Credelio Quattro and five dogs administered the active control had bloody diarrhea. Clinical Sign Credelio QuattroN=191Number (Percentage) Active ControlN=181Number (Percentage) Diarrhea, with or without blood 21 (11%) 15 (8.3%) Vomiting 18 (9.4%) 8 (4.4%) Lethargy 12 (6.3%) 1 (0.6%) Anorexia 11 (5.8%) 5 (2.8%) Dermatitis 10 (5.2%) 8 (4.4%) Weight Loss 6 (3.1%) 3 (1.7%) Pruritus (itching) 3 (1.6%) 1 (0.6%) Alopecia (hair loss) 2 (1.0%) 4 (2.2%) Seizure 1 (0.5%) 4 (2.2%) Ataxia 1 (0.5%) 1 (0.6%) Nystagmus 1 (0.5%) 0 (0.0%) Anisocoria 1 (0.5%) 1 (0.6%) One geriatric dog receiving Credelio Quattro experienced two episodes of vomiting, ataxia, and nystagmus, 11 days apart, with the first episode occurring two days after the eighth dose. The dog recovered within 24 hours after the first episode and 1 hour after the second episode and completed the study. One dog receiving Credelio Quattro was observed by the investigator to have anisocoria during scheduled physical examinations one month after the ninth dose and one month after the eleventh dose. In a second U.S. field safety and effectiveness study, Credelio Quattro was administered to 103 dogs with hookworms. Adverse reactions in dogs treated with Credelio Quattro included gastrointestinal signs (diarrhea, emesis) and lethargy. In a U.S. field study, 165 dogs received a combination of lotilaner, moxidectin, and praziquantel, three of the active ingredients at the same doses as in Credelio Quattro