Loteprednol Etabonate (8 brand names, 3 dosage forms, 1 route)
Available dosage forms: SUSPENSION/DROPS, GEL, OINTMENT.
Routes of administration: OPHTHALMIC.
Brand Names
- ALREX
- EYSUVIS
- INVELTYS
- LOTEMAX
- LOTEMAX SM
- LOTEPREDNOL ETABONATE
- LOTEPREDNOL ETABONATE AND TOBRAMYCIN
- ZYLET
Indications and Usage
INVELTYS is a corticosteroid indicated for the treatment of post-operative inflammation and pain following ocular surgery.
Dosage and Administration
Instill one to two drops of INVELTYS into the affected eye twice daily beginning the day after surgery and continuing throughout the first 2 weeks of the post-operative period.
Contraindications
INVELTYS is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures.
Adverse Reactions
Adverse reactions associated with ophthalmic steroids include elevated intraocular pressure, which may be associated with infrequent optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, delayed wound healing and secondary ocular infection from pathogens including herpes simplex, and perforation of the globe where there is thinning of the cornea or sclera.
Mechanism of Action
Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation. While glucocorticoids are known to bind to and activate the glucocorticoid receptor, the molecular mechanisms involved in glucocorticoid/glucocorticoid receptor-dependent modulation of inflammation are not clearly established. However, corticosteroids are thought to inhibit prostaglandin production through several independent mechanisms.