Lipase (6 brand names, 3 dosage forms, 1 route)
Available dosage forms: CAPSULE, CAPSULE, DELAYED RELEASE, TABLET.
Routes of administration: ORAL.
Brand Names
- COTAZYM
- CREON
- PANCREAZE
- PERTZYE
- VIOKACE
- ZENPEP
Indications and Usage
ZENPEP® is indicated for the treatment of exocrine pancreatic insufficiency in adult and pediatric patients.
Contraindications
None.
Adverse Reactions
The following serious or otherwise important adverse reactions are described elsewhere in the labeling: Fibrosing Colonopathy [see Warnings and Precautions (5.1)] Irritation of the Oral Mucosa [see Warnings and Precautions (5.2)] Hyperuricemia [see Warnings and Precautions (5.3)] Risk of Viral Transmission [see Warnings and Precautions (5.4)] Hypersensitivity Reactions [see Warnings and Precautions (5.5)]
Mechanism of Action
Pancreatic enzyme products contain a mixture of lipases, proteases, and amylases that catalyze the hydrolysis of fats to monoglycerides, glycerol, and free fatty acids, protein into peptides and amino acids, and starch into dextrins and short chain sugars such as maltose and maltriose in the duodenum and proximal small intestine, thereby acting like digestive enzymes physiologically secreted by the pancreas.
Overdosage
Chronic high dosages of pancreatic enzyme products have been associated with fibrosing colonopathy and colonic strictures [see Warnings and Precautions (5.1)]. High dosages of pancreatic enzyme products have been associated with hyperuricosuria and hyperuricemia [see Warnings and Precautions (5.3)].