Levoleucovorin (1 brand name, 1 dosage form, 1 route)
Available dosage forms: POWDER.
Routes of administration: INTRAVENOUS.
Brand Names
- KHAPZORY
Indications and Usage
KHAPZORY is indicated for: rescue after high-dose methotrexate therapy in adult and pediatric patients with osteosarcoma. diminishing the toxicity associated with overdosage of folic acid antagonists or impaired methotrexate elimination adult and pediatric patients. The treatment of adults with metastatic colorectal cancer in combination with fluorouracil. Limitations of Use KHAPZORY is not indicated for pernicious anemia and megaloblastic anemia secondary to lack the of vitamin B12 because of the risk of progression of neurologic manifestations despite hematologic remission.
Contraindications
KHAPZORY is contraindicated in patients who have had severe hypersensitivity to leucovorin products, folic acid, or folinic acid [see Adverse Reactions (6.2)].
Adverse Reactions
The following clinical significant adverse reactions are described elsewhere in the labeling: •Increased gastrointestinal toxicities with fluorouracil [see Warnings and Precautions (5.1)]